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- W3032172898 abstract "当前第二代超声造影技术已经基本成熟，声诺维（SonoVue）已经得到了大规模的临床应用，并取得了较好的效果[1-2]。以声诺维为代表的这类造影剂是一种微米级的血池显影剂可获得组织的血流灌注信息，但是其对肿瘤组织的显影实际上是肿瘤血管显影。由于肿瘤血管存在的高通透性和滞留（enhanced permeability and retention，EPR）效应，所以现阶段研究者们开始研制能够穿越肿瘤血管内皮间隙的纳米级造影剂，可直接与肿瘤组织结合，达成肿瘤组织的血管外分子显影[3]。氟碳类纳米微粒具有粒径小、稳定性强等优势，是一种潜在的纳米级超声造影剂。现就氟碳类纳米微粒的构建情况及在肿瘤靶向超声显影方面的研究综述如下。" @default.
- W3032172898 created "2020-06-05" @default.
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- W3032172898 date "2014-11-25" @default.
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- W3032172898 title "Research progress in preparation and tumor-targeted ultrasonic imaging of fluorocarbon nanoparticles" @default.
- W3032172898 doi "https://doi.org/10.3760/cma.j.issn.1004-4477.2014.11.026" @default.
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