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- W3032174014 abstract "Objective To study clinical value of echocardiography in prenatal diagnosis,classification and follow-up after birth of isolated ventricular septal defect (i-VSD).Methods In 6145 fetuses undergoing fetal echocardiography,95 fetuses were diagnosed with i-VSD.The characteristics of fetal echocardiography,pathological classification of i-VSD,findings of genetic examination and follow-up of evolution of VSD were analyzed.Results In 95 fetuses with i-VSD,color Doppler flow imaging displayed bi-directional shunts at the ventricular level.Defect sizes ranged from 0.9 mm to 13.4 mm,averaged (3.3 ± 2.0)mm.There were 60 cases (63.2％) with perimembranous i-VSD,33 cases (34.7％) with muscular i-VSD,1 cases (1.1％)with subarterial i-VSD,1 cases (1.1％) with multiple i-VSD.Chromosome tests were performed successfully in 32 cases.Among these cases,there were 3 cases (9.4％) with Trisomy 21,1 case (3.12％)with Trisomy 18 and 28 cases with normal chromosomes.Among the cases,14 were lost to follow-up,50 were life labor,5 were stillbirth,23 were induced abortion and 3 had not finished follow-up.Among 50 cases of life labor,VSD were naturally closed in 13 cases (25％) prenatally or in one year after the birth.VSD were surgically repaired in 2 cases after birth.35 cases were still under follow-up.Conclusions Solitary and perimembranous i-VSDs were the most common types.Part of fetal i-VSDs naturally closed after birth.Prenatal i-VSD is a valuable suggestive clue for genetic abnormalities.Echocardiography has an important value in prenatal diagnosis,follow-up and treatment of VSD and may play an important role in predicting fetal genetic abnormality.Key words: Ultrasonography,prenatal; Heart septal defect,ventricular; Chromosome aberrations" @default.
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- W3032174014 date "2013-05-25" @default.
- W3032174014 modified "2023-09-26" @default.
- W3032174014 title "Clinical value of echocardiography in prenatal diagnosis, classification and follow-up of evolution in fetal isolated ventricular septal defect" @default.
- W3032174014 doi "https://doi.org/10.3760/cma.j.issn.1004-4477.2013.05.011" @default.
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