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- W3032178738 abstract "ObjectiveTo investigate the effect of prenatal nicotine exposure (PNE) on cardiac function in adult offspring rats.MethodThe female SD rats were randomly divided into PNE group and control group, and continuously exposed to either nicotine (8 mg·kg-1·d-1) or saline via subcutaneous osmotic mini pumps throughout gestation.The body weight, heart weight, blood pressure and heart rate were observed in their offspring.The cardiac structure and function of the offspring were examined by echocardiography, and the hemodynamics of left ventricle and aorta was evaluated by cardiac catheterization.ResultsThere was no significant difference in the weight, heart/body weight ratio, heart rate, blood pressure, diastolic thickness of ventricular septal (SWTd), left ventricular posterior wall diastolic thickness (LVPWTd), left ventricular diastolic end diameter (LVEDD) and left ventricular systolic end diameter (LVESD) of the offspring rats between the PNE group and the control (all P>0.05). The left ventricular diastolic volume (LVEDV) (0.37 cm±0.11 cm vs 0.59 cm±0.09 cm, P 0.05). Compared with the control group, the maximum rate of left ventricular pressure rise (+ dp/dtmax) increased significantly (all P<0.05), while the maximum rate of left ventricular pressure decrease (-dp/dtmax) significantly reduced (all P<0.05) in both female and male PNE offspring with a particularly prominent reduction in the male.ConclusionPNE can induce abnormal cardiac function in adult offspring rats, which is characterized by diastolic function injury, with preserved or even compensatory elevated systolic function, and significant decreased cardiac output performance.These effects of PNE were particularly apparent in the male offspring and displayed a gender related manner.Key words: Nicotine; Prenatal exposure delayed effects; Rats" @default.
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- W3032178738 date "2018-06-15" @default.
- W3032178738 modified "2023-09-24" @default.
- W3032178738 title "Prenatal nicotine exposure induces impaired cardiac function in adult offspring rats" @default.
- W3032178738 doi "https://doi.org/10.3760/cma.j.issn.2096-3076.2018.06.008" @default.
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