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- W3032185251 abstract "Objective To investigate the expression of transcription factor AP-2α and CEA in the process of occurrence and development of colorectal cancer and the correlation between the two transcription factors.Methods The expression levels of AP-2α and CEA mRNA in 60 colon cancer tissues and corresponding normal tissues were detected by Real-time PCR and the results with the clinical features and pathological characters were analyzed.The relationship between the expression of AP-2α mRNA and CEA mRNA in 60 colon cancer tissues was analyzed.Results The expression levels of CEA mRNA was higher in colon cancer tissues than that in the matched normal tissues (P ＜0.01),whereas the expression levels of AP-2α mRNA in the colon cancer tissues was significantly lower than that in the matched normal tissues (P ＜0.01).There was no significant correlation between AP-2α,CEA mRNA expression levels and age,sex,tumor location (P ＞ 0.05).Loss expression or down regulation expression of AP-2α mRNA was detected,whereas CEA mRNA was highly expressed in the different histological grade and Dukes stages.The expression of AP-2α mRNA and CEA mRNA was positively correlated with the histological grade in colon cancer.A negative correlation was found between the expression of AP-2α mRNA and CEA mRNA (r =-0.790,P ＜ 0.01).Conclusions The expression of AP-2αmRNA is down-regulated or lossed,whereas CEA is highly expressed in colon cancer.There is negative correlation between the expression of AP-2α mRNA and CEA mRNA,indicating that AP-2α and CEA may provide the new clues of diagnosis and treatment of tumor.Key words: Colon cancer; Transcription factor activator protein-2α; Carcinoembryonic antigen; Real-time PCR" @default.
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- W3032185251 date "2012-12-25" @default.
- W3032185251 modified "2023-09-22" @default.
- W3032185251 title "Expression of transcription factor AP-2α and CEA in colon cancer and the correlation between the two factors" @default.
- W3032185251 doi "https://doi.org/10.3760/cma.j.issn.1674-4756.2012.24.003" @default.
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