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- W3032186186 abstract "Objective To study the key proteins associated with metastasis of gastric cancer,and the potential diagnostic markers and therapeutic targets of this malignancy.Methods A comparative proteomic strategy,in a combination of two-dimensional electrophoresis separation and mass spectrometry identification,was adopted to search for proteome alternations in an gastric cancer mother cell line BGC823 and its highly peritoneal metastatic cell subline SCG7901.Results There were 20 significant proteins identified in total.Among the 20 spots,11 proteins were up-regulated in cell line SCG7901,whereas 9 were up-regulated in cell line BGC823.Western blotting confirmed the difference of forkhead box P3 (Foxp3) on protein level.Conclusion The results suggest that an obviously differential proteomic expression exists between the human gastric cancer mother cell line BGC823 and its highly peritoneal metastatic cell subline SCG7901.Key words: Gastric cancer; Peritoneal metastasis; Proteomics" @default.
- W3032186186 created "2020-06-05" @default.
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- W3032186186 date "2013-02-08" @default.
- W3032186186 modified "2023-09-25" @default.
- W3032186186 title "Comparative proteomics studies related to peritoneal metastasis in gastric cancer" @default.
- W3032186186 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2013.02.003" @default.
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