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- W3032199134 abstract "ObjectiveTo investigate changes in subretinal fluid(SRF), intraretinal fluid(IRF)and visual acuity after treatment with anti-vascular endothelial growth factor(VEGF)drugs in patients with wet age-related macular degeneration(WAMD)combined with disseminated epithelial detachment(PED).MethodsThirty-one WAMD patients with PED were retrospectively analyzed.Imaging characteristics of retinal morphological changes and changes in visual acuity were analyzed by optical coherence tomography(OCT)before and after treatment with Ranibizumab(1 mg).ResultsThirty-one patients were treated with regular doses 3 to 17 times.WAMD patients with persistent/recurrent SRF, IRF and PED were treated with Ranibizumab(1 mg)1 to 3 times.There was a significant difference in the mean central retinal thickness(CRT)before and after 1 month of treatment(498.5±242.9 μm vs.406.0±201.9 μm, t=6.025, P<0.01).85.7% of patients(24 cases)had a decrease in SRF, 60%(9 cases)had a decrease in IRF and 67.7%(10 patients)had a decrease in PED, and 19 patients(32.7%)had increased visual acuity assessed by the Early Treatment of Diabetic Retinopathy Study(ETDRS)chart(≥ 5 letters), and 36 patients(61.2%)had stable vision.ConclusionsIntravitreal injection of 1 mg Ranibizumab for the treatment of WAMD patients with PED can improve or stabilize visual acuity and reduce SRF, IRF and PED.Key words: Macular degeneration; Pigment epithelial of eye; Choroidal neovascularization" @default.
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- W3032199134 date "2019-04-14" @default.
- W3032199134 modified "2023-09-23" @default.
- W3032199134 title "Clinical efficacy of Ranibizumab for exudative age-related macular degeneration" @default.
- W3032199134 doi "https://doi.org/10.3760/cma.j.issn.0254-9026.2019.04.018" @default.
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