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- W3032199797 abstract "ObjectiveTo discuss the relationship between liver elastic modulus and liver histological grade in chronic hepatitis B (CHB) patients with low viral load (HBV DNA≤20 000 IU/mL) by real time shear wave elastic imaging (SWE) .MethodsA total of 99 CHB patients with low viral load in Hangzhou Normal University Affiliated Hospital from April 2016 to June 2018 were enrolled. SWE was performed to detect liver elastic modulus. Pathological results by liver biopsy, as the gold standard, was used to determine different stages of liver inflammation (G) and fibrosis (S) . The correlation between the degree of hepatic fibrosis and liver elastic modulus were analyzed, and ROC curve was used to evaluate the diagnostic value of SWE.ResultsThe values of elastic modulus had significant differences in different stage groups of liver inflammation (G) [(7.357±0.160), (7.425±1.267), (10.39±7.858), (14.886±1.905)kPa]and fibrosis (S) [(5.855±0.109), (7.184±0.229), (8.279±0.651), (13.518±0.552), (16.267±0.463)kPa] (P 0.05) . The values of liver elastic modulus were moderately positively correlated with inflammatory activity grade (r=0.593, P<0.05) and fibrosis stage (r=0.799, P<0.05) . The area under curve (95%CI) of SWE for liver inflammation G≥2 in CHB patients with low viral load was 0.828 (0.741-0.914) and for liver fibrosis S≥2 was 0.906 (0.847-0.966).ConclusionsSWE technology can continuously and dynamically monitor the degree of liver inflammation and fibrosis in CHB patients with low viral load.Key words: Hepatitis B, chronic; Real time shear wave elastography; Low viral load; Liver inflammation; Hepatic fibrosis" @default.
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- W3032199797 date "2019-12-25" @default.
- W3032199797 modified "2023-09-27" @default.
- W3032199797 title "Clinical significance of real time shear wave elastography in assessment of liver pathological grade in chronic hepatitis B patients with low viral load" @default.
- W3032199797 doi "https://doi.org/10.3760/cma.j.issn.1673-4149.2019.06.006" @default.
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