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- W3032201345 abstract "Objective To understand the effect of immediately prolonged context exposure on cued conditioning.Methods Prolonged or not prolonged traumatic context exposure(rats stayed 90 minutes or 2 minutes in train context after the last light-shock trial,that was 90 min group or 2 min group respectively)immediately after visual Pavlov fear conditioning train to extinct the fear response to traumatic context.Results Results showed that contextual fear memory was an important factor modulating cued conditioned fear response of rats.In traumatic context,the fear response to conditioned light of 90 min group was marginally significant low compared with 2 min group[freezing levels were(19.531±6.073)%,(46.094±10.427)%respectively,P=0.085],and the decrease of fear expression of 90 min group could last at least 35 days[freezing levels were(21.094±4.897)%,(74.219±9.481)%respectively for groups,P＜0.01].Conclusion Immediately prolonged context exposure transfer the traumatic context as asafe occasion setter,then decreased the fear response to discrete conditioned cues.This suggests that immediately prolong the traumatic environment exposure time might be a favorable way to prevent posttraumatic stress disorder.Key words: Context exposure ; Contextual conditioned fear ; Cued conditioned fear ; Occasion setting ; Posttraumatic stress disorder ;" @default.
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- W3032201345 date "2009-09-20" @default.
- W3032201345 modified "2023-09-25" @default.
- W3032201345 title "Effect of prolonged traumatic context exposure on conditioned fear response" @default.
- W3032201345 doi "https://doi.org/10.3760/cma.j.issn.1674-6554.2009.09.003" @default.
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