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- W3032226992 abstract "Objective To compare the efficacy of epidural morphine with and without transnasal butorphanol on postoperative pain relief following abdominal hysterectomy.Methods This is A single-blind design,randomized,placebo controlled study. 50 patients (ASA Ⅰ～Ⅱ)undergoing total abdominal hysterectomies was conducted to group A and group B (n=25). Following elective abdominal hysterectomy with epidural anesthesia via L2-3,group A of 25 patients received a single epidural bolus of morphine (0.5 mg) with transnasal saline as placebo analgesia (0.1 ml,q4 h),and group B received a single epidural bolus of morphine (0.5 mg) combined with transnasal butorphanol 1 mg ( 0.1 ml,q4 h) for postoperative analgesia. Parameters monitored were pain pulse,respiratory rate,SPO2 and side effects such as nausea,emesis,skin itching and delayed score (Visual Analogue Scale,VAS),sedation score (Remesay sedation score,RSS),blood pressure,respiratory depression.Results Compared with group A,the VAS scores were found to be decreased in group B significantly from 20 h to 32 h after epidural analgesia (P＜ 0.01 ). There was a significant difference in analgesics-effect curve (AUC) (P＜ 0.01 ) between two groups. The incidences of complications were equally comparable in both two groups.Conclusion Single epidural bolus of morphine 0.5 mg with regularly transnasal Butorphanol (1mg,q4h) had a better analgesic effect than placebo analgesia,which is easier to perform in pain management and is practicable for abdominal hysterectomy in the primary hospital.Key words: Morphine; Epidural; Post-operative anesthesia; Transnasal butorphanol; Combined analgesia; Placebo analgesia" @default.
- W3032226992 created "2020-06-05" @default.
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- W3032226992 date "2011-02-15" @default.
- W3032226992 modified "2023-09-25" @default.
- W3032226992 title "Effectiveness and safety of epidural bolus injection of low dose morphine combined with transnasal butorphanol on postoperative analgesia in abdominal hysterectomy" @default.
- W3032226992 doi "https://doi.org/10.3760/cma.j.issn.1673-4378.2011.02.008" @default.
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