Matches in SemOpenAlex for { <https://semopenalex.org/work/W3032237628> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W3032237628 endingPage "243" @default.
- W3032237628 startingPage "238" @default.
- W3032237628 abstract "ObjectiveTo evaluate the tonic and health effects of Xuebijing injection, a traditional Chinese medicine injection, by means of corn low-nutritional mice model combined with benefit-damage index-general score (BDI-GS) evaluation system under a physiological dosage. Further, to investigate the scientific and practical benefits of the evaluation system in efficacy and safety re-evaluation of clinical traditional Chinese medicine injections.MethodsHealthy ICR mice during growth period were randomly divided into blank control group and low, middle and high dose groups. All the mice were fed with corn diets, and treated by intraperitoneal injection once a day. The mice in the blank control group were injected with 0.4 ml 0.9% sodium chloride injection, and the mice in the low, medium and high dose groups were injected with 0.2, 0.4 and 0.6 ml Xuebijing injection, respectively, for seven days. On the 8th day, the mice were killed, dissected, and took nine kinds of organs including heart, lung, thymus, spleen, pancreas, kidney, gonad and femur. The weight BDI, index BDI and the corresponding weight BDI general score (GSW) and index BDI general score (GSI) were calculated, and the serum biochemical parameters were measured.ResultsUnder the physiological dose, Xuebijing injection shows good safety of continuous infusion, tonic and health effects, and slight damages on the rest of organs. More specifically, the values of weight BDI and index BDI were all higher than 9.0, and values of GSW and GSI were all higher than the basic value of 9.0. Furthermore, these parameters increased in a dose-dependent manner. In addition, the total protein level of (47.6 ± 4.30) g/L in the high dose groups was significantly higher than (43.18 ± 2.60) g/L in the blank control group (P< 0.05).ConclusionsThe Xuebijing injection has a lower risk for conventional usage. This injection is safe under the physiological dosage and much safer in higher dosage designed in this study. The low-nutritional model combined with BDI-GS evaluation system can be used for re-evaluating the function and safety of clinical traditional Chinese medicine injections.Key words: Benefit-damage index-general score system; Low-nutritional model; Xuebijing Injection; Safety evaluation" @default.
- W3032237628 created "2020-06-05" @default.
- W3032237628 creator A5005661615 @default.
- W3032237628 creator A5015905956 @default.
- W3032237628 creator A5025362732 @default.
- W3032237628 creator A5062183746 @default.
- W3032237628 creator A5066306211 @default.
- W3032237628 creator A5071959801 @default.
- W3032237628 date "2017-08-28" @default.
- W3032237628 modified "2023-09-22" @default.
- W3032237628 title "Function and safety re-evaluation of Xuebijing injection, a traditional Chinese medicine injection" @default.
- W3032237628 doi "https://doi.org/10.3760/cma.j.issn.1673-4181.2017.04.004" @default.
- W3032237628 hasPublicationYear "2017" @default.
- W3032237628 type Work @default.
- W3032237628 sameAs 3032237628 @default.
- W3032237628 citedByCount "0" @default.
- W3032237628 crossrefType "journal-article" @default.
- W3032237628 hasAuthorship W3032237628A5005661615 @default.
- W3032237628 hasAuthorship W3032237628A5015905956 @default.
- W3032237628 hasAuthorship W3032237628A5025362732 @default.
- W3032237628 hasAuthorship W3032237628A5062183746 @default.
- W3032237628 hasAuthorship W3032237628A5066306211 @default.
- W3032237628 hasAuthorship W3032237628A5071959801 @default.
- W3032237628 hasConcept C126322002 @default.
- W3032237628 hasConcept C142724271 @default.
- W3032237628 hasConcept C147583825 @default.
- W3032237628 hasConcept C188947578 @default.
- W3032237628 hasConcept C204787440 @default.
- W3032237628 hasConcept C2780091579 @default.
- W3032237628 hasConcept C2780159080 @default.
- W3032237628 hasConcept C2780931953 @default.
- W3032237628 hasConcept C42219234 @default.
- W3032237628 hasConcept C71924100 @default.
- W3032237628 hasConcept C98274493 @default.
- W3032237628 hasConceptScore W3032237628C126322002 @default.
- W3032237628 hasConceptScore W3032237628C142724271 @default.
- W3032237628 hasConceptScore W3032237628C147583825 @default.
- W3032237628 hasConceptScore W3032237628C188947578 @default.
- W3032237628 hasConceptScore W3032237628C204787440 @default.
- W3032237628 hasConceptScore W3032237628C2780091579 @default.
- W3032237628 hasConceptScore W3032237628C2780159080 @default.
- W3032237628 hasConceptScore W3032237628C2780931953 @default.
- W3032237628 hasConceptScore W3032237628C42219234 @default.
- W3032237628 hasConceptScore W3032237628C71924100 @default.
- W3032237628 hasConceptScore W3032237628C98274493 @default.
- W3032237628 hasIssue "4" @default.
- W3032237628 hasLocation W30322376281 @default.
- W3032237628 hasOpenAccess W3032237628 @default.
- W3032237628 hasPrimaryLocation W30322376281 @default.
- W3032237628 hasRelatedWork W2266255526 @default.
- W3032237628 hasRelatedWork W2348438182 @default.
- W3032237628 hasRelatedWork W2348795366 @default.
- W3032237628 hasRelatedWork W2349238605 @default.
- W3032237628 hasRelatedWork W2349856221 @default.
- W3032237628 hasRelatedWork W2350005648 @default.
- W3032237628 hasRelatedWork W2353319048 @default.
- W3032237628 hasRelatedWork W2361359678 @default.
- W3032237628 hasRelatedWork W2364489119 @default.
- W3032237628 hasRelatedWork W2365817751 @default.
- W3032237628 hasRelatedWork W2368167569 @default.
- W3032237628 hasRelatedWork W2370097648 @default.
- W3032237628 hasRelatedWork W2373001897 @default.
- W3032237628 hasRelatedWork W2374970498 @default.
- W3032237628 hasRelatedWork W2379676943 @default.
- W3032237628 hasRelatedWork W2380065594 @default.
- W3032237628 hasRelatedWork W2381058860 @default.
- W3032237628 hasRelatedWork W2389007616 @default.
- W3032237628 hasRelatedWork W2597447154 @default.
- W3032237628 hasRelatedWork W3029735088 @default.
- W3032237628 hasVolume "40" @default.
- W3032237628 isParatext "false" @default.
- W3032237628 isRetracted "false" @default.
- W3032237628 magId "3032237628" @default.
- W3032237628 workType "article" @default.