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- W3032241531 abstract "ObjectiveTo observe autophagy of keloid fibroblasts induced by resveratrol and explore the possible mechanism.MethodsThe cultured in vitro fibroblasts from patients with keloid were harvested and divided into control group and resveratrol (20, 40, 80, 160 μmol/L) groups. After treatment for 24, and 48 h, cell activity was determined by methyl thiazol tetrazolium (MTT) assay. Real-time fluorescent quantitative polymerase chain reaction (FQ-PCR) was used to examine the expression level of microtubule-associated protein 1 light chain 3 (LC3)-Ⅱ and Becline 1. Enzyme linked immunosorbent assay (ELISA) was used to detect the expression level of LC3-Ⅱ and Becline 1.ResultsResveratrol could significantly inhibit the growth of fibroblasts in vitro in a concentration- and time-dependent manner, and the inhibition rate increased from 4.9% to 43.7% with increase of concentration and prolongation of time. After treatment, keloid fibroblasts autophagy-related protein LC3-Ⅱ and beclin1 mRNA relative expression increased, from (1.367±0.141) to (4.562±0.371) times, and (1.232±0.189) to (3.603±0.297) times, respectively.ConclusionResveratrol can effectively promote the production of protein LC3-Ⅱ and Beclin 1, increase the level of autophagy in keloid fibroblasts, and inhibit the growth of fibroblasts.Key words: Resveratrol; Keloid; Fibroblast; Autophagy" @default.
- W3032241531 created "2020-06-05" @default.
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- W3032241531 date "2016-12-08" @default.
- W3032241531 modified "2023-09-23" @default.
- W3032241531 title "Effect of resveratrol on autophagy in keloid fibroblasts" @default.
- W3032241531 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2016.12.019" @default.
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