Matches in SemOpenAlex for { <https://semopenalex.org/work/W3032242593> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W3032242593 endingPage "836" @default.
- W3032242593 startingPage "833" @default.
- W3032242593 abstract "Objective To investigate the effects of different afferent nerve injury on development of neuropathic pain and its relationship with brain-derived neurotrophic factor （BDNF） in spinal cord and dorsal root ganglion （DRG） in rats. Methods Twenty-four male SD rats aged 2 months weighing 200-250 g were randomly divided into 3 groups： group I sham operation （group S） ; group II sural nerve injury （group SUR） and group Ill gastrocnemius-soleus nerve injury （group GS）. Sural nerve and gastrocnemius-soleus nerve were transected in group SUR and GS respectively. Paw withdrawal threshold to yon Frey filament stimulation was measured the day before and at day 3 and 7 after operation. The animals were killed at postoperative day 7 after the measurement of paw withdrawal threshold. The ipsilateral L5 DRG and L5 segment of the spinal cord were removed. BDNF expression in the spinal dorsal horn was determined. The percentage of BDNF positive neurons and ATF-3 positive neurons in the total DRG neurons and the percentage of BDNF positive neurons in the damaged neurons （ATF-3 positive） were calculated. Results Mechanical hyperalgesia developed after transection of gastrocnemius-soleus muscle in group GS. Mechanical pain threshold was sinificantly lower, while BDNF expression in the spinal dorsal horn and the percentage of BDNF positive neurons in total DRG neurons were significantly higher in group GS than in group S and SUR （P 〈 0.01）. There was no significant difference in all variables between group SUR and S （ P 〉 0.05）. There was no significant difference in the percentage of ATF-3 positive neurons in the total DRG neurons between group GS and SUR （ P 〉 0.05 ）, but the percentage of BDNF positive neurons in the damaged neurons （ATF-3 positive） was significantly higher in group GS than in group SUR （P 〈 0.05）. Conclusion Transection of the afferent nerve innervating muscle can produce neuropathic pain through up-regulation of BDNF expression in spinal dorsal horn and DRG in rats, while transection of the afferent nerve innervating skin can not.Key words: Afferent pathways; Neuralgia; Brain-derived neurotrophic factor; Spinal cord; Ganglia, spinal" @default.
- W3032242593 created "2020-06-05" @default.
- W3032242593 creator A5008740825 @default.
- W3032242593 creator A5021995750 @default.
- W3032242593 creator A5050705963 @default.
- W3032242593 creator A5069688429 @default.
- W3032242593 date "2010-07-20" @default.
- W3032242593 modified "2023-09-25" @default.
- W3032242593 title "Effects of different afferent nerve injury on development of neuropathic pain and its relationship with brain-derived neurotrophic factor in spinal cord and dorsal root ganglion in rats" @default.
- W3032242593 doi "https://doi.org/10.3760/cma.j.issn.0254-1416.2010.07.022" @default.
- W3032242593 hasPublicationYear "2010" @default.
- W3032242593 type Work @default.
- W3032242593 sameAs 3032242593 @default.
- W3032242593 citedByCount "0" @default.
- W3032242593 crossrefType "journal-article" @default.
- W3032242593 hasAuthorship W3032242593A5008740825 @default.
- W3032242593 hasAuthorship W3032242593A5021995750 @default.
- W3032242593 hasAuthorship W3032242593A5050705963 @default.
- W3032242593 hasAuthorship W3032242593A5069688429 @default.
- W3032242593 hasConcept C105702510 @default.
- W3032242593 hasConcept C118552586 @default.
- W3032242593 hasConcept C126322002 @default.
- W3032242593 hasConcept C134018914 @default.
- W3032242593 hasConcept C15490471 @default.
- W3032242593 hasConcept C160539049 @default.
- W3032242593 hasConcept C170493617 @default.
- W3032242593 hasConcept C2775991916 @default.
- W3032242593 hasConcept C2776281502 @default.
- W3032242593 hasConcept C2777107010 @default.
- W3032242593 hasConcept C2778423431 @default.
- W3032242593 hasConcept C2778790584 @default.
- W3032242593 hasConcept C2779245659 @default.
- W3032242593 hasConcept C2780775167 @default.
- W3032242593 hasConcept C2780923182 @default.
- W3032242593 hasConcept C42219234 @default.
- W3032242593 hasConcept C71924100 @default.
- W3032242593 hasConceptScore W3032242593C105702510 @default.
- W3032242593 hasConceptScore W3032242593C118552586 @default.
- W3032242593 hasConceptScore W3032242593C126322002 @default.
- W3032242593 hasConceptScore W3032242593C134018914 @default.
- W3032242593 hasConceptScore W3032242593C15490471 @default.
- W3032242593 hasConceptScore W3032242593C160539049 @default.
- W3032242593 hasConceptScore W3032242593C170493617 @default.
- W3032242593 hasConceptScore W3032242593C2775991916 @default.
- W3032242593 hasConceptScore W3032242593C2776281502 @default.
- W3032242593 hasConceptScore W3032242593C2777107010 @default.
- W3032242593 hasConceptScore W3032242593C2778423431 @default.
- W3032242593 hasConceptScore W3032242593C2778790584 @default.
- W3032242593 hasConceptScore W3032242593C2779245659 @default.
- W3032242593 hasConceptScore W3032242593C2780775167 @default.
- W3032242593 hasConceptScore W3032242593C2780923182 @default.
- W3032242593 hasConceptScore W3032242593C42219234 @default.
- W3032242593 hasConceptScore W3032242593C71924100 @default.
- W3032242593 hasIssue "07" @default.
- W3032242593 hasLocation W30322425931 @default.
- W3032242593 hasOpenAccess W3032242593 @default.
- W3032242593 hasPrimaryLocation W30322425931 @default.
- W3032242593 hasRelatedWork W1986344477 @default.
- W3032242593 hasRelatedWork W1992832141 @default.
- W3032242593 hasRelatedWork W2007730810 @default.
- W3032242593 hasRelatedWork W2025388917 @default.
- W3032242593 hasRelatedWork W2071118911 @default.
- W3032242593 hasRelatedWork W2133138877 @default.
- W3032242593 hasRelatedWork W2350237471 @default.
- W3032242593 hasRelatedWork W2370601348 @default.
- W3032242593 hasRelatedWork W2372790602 @default.
- W3032242593 hasRelatedWork W2373581123 @default.
- W3032242593 hasRelatedWork W2376202340 @default.
- W3032242593 hasRelatedWork W2380079626 @default.
- W3032242593 hasRelatedWork W2382032738 @default.
- W3032242593 hasRelatedWork W2383463117 @default.
- W3032242593 hasRelatedWork W2398215464 @default.
- W3032242593 hasRelatedWork W2590479034 @default.
- W3032242593 hasRelatedWork W2601813100 @default.
- W3032242593 hasRelatedWork W3029651469 @default.
- W3032242593 hasRelatedWork W3032346133 @default.
- W3032242593 hasRelatedWork W942078448 @default.
- W3032242593 hasVolume "30" @default.
- W3032242593 isParatext "false" @default.
- W3032242593 isRetracted "false" @default.
- W3032242593 magId "3032242593" @default.
- W3032242593 workType "article" @default.