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• W3032243119 abstract "ObjectiveTo explore the relationship between MTHFR gene polymorphism and lung cancer in Han population of Heilongjiang Province.MethodsTwo hundred and twenty-five lung cancer patients were selected as the experimental group and the healthy subjects in the outpatient physical examination as the control group, A case-control study was used to analyze the association of MTHFR gene 677C/T, 1298A/C SNP and lung cancer, and the gene typing was detected by Sanger double deoxidization chain termination method.ResultsIn the control group, the frequencies of wild-type CC, mutant heterozygote CT, and homozygous TT genotypes of the MTHFR gene C677T were 34.2%, 55.1%, and 10.7%, respectively.The frequencies of the three genotypes in the experimental group were 26.7%, 50.2%, 23.1%, respectively.The difference in the distribution of C677T SNP genotype frequencies of the experimental group and the control group was statistically significant (P=0.002), in which the mutation homozygous TT carriers were 2.78 times more likely to develop lung cancer than wild-type CC(OR(95%CI): 2.78(1.54~5.02) , P=0.001); AA, AC and CC genotype frequencies of the A1298C locus of the MTHFR gene were 34.2%, 55.1%, and 10.7%, respectively, and the control group was 64.0%.32.0%, 4.0%, there was no significant difference between the two groups (P=0.247). The frequencies of AA, AC and CC genotypes in the A1298C locus of the MTHFR gene were 34.2%, 55.1%, and 10.7%, respectively, and 64.0%, 32.0%, and 4.0% in the control group, respectively.There was no significant difference between the two groups (P). =0.247). The haploid analysis showed that the distribution frequency of TA haplotype in the experimental group was significantly higher than that in the control group (43.1% vs.35.3%). There was a statistically significant difference between the two groups (OR(95%CI): 1.39 (1.06-1.81), P=0.016); while the frequencies of CC haplotypes in the experimental group and the control group were 10.6% and 17.1%, respectively.The difference was statistically significant (OR(95%CI): 0.58 (0.39-0.85). P=0.005). There was a linkage disequilibrium between the two points of MTHFR gene 677 and 1298 (D'=0.48, P=0.003). The gene-environment interaction analysis of the MTHFR gene C677T polymorphism showed that based on the comparison between TT and CC genotype, age over 60 (OR(95%CI): 4.0(1.78-9.32), P=0.001), male (OR (95%CI): 5.55 (2.10-14.67), P=0.000), smoking (OR(95%CI): 8.13 (2.29-28.85), P=0.000) and small cell lung cancer (OR (95%CI) : 1.28 (1.10-1.44), P=0.000) can increase the risk of lung cancer; based on the comparison between CT and CC genotype, women (OR(95%CI): 2.09 (1.05-4.16), P=0.030), non-smoking population (OR(95%CI): 2.43 (1.25-4.74), P=0.008) and small cell lung cancer (OR (95% CI): 0.31 (1.16-1.59), P=0.000) can increase the risk of lung cancer.ConclusionMTHFR gene C677T is a genetic susceptibility gene for lung cancer and is associated with the risk of lung cancer.Key words: Methylenetetrahydrofolate reductase; SNP; Lung cancer" @default.
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• W3032243119 date "2018-05-01" @default.
• W3032243119 modified "2023-09-23" @default.
• W3032243119 title "Relationship between methylenetetrahydrofolate reductase gene 677C / T, 1298A / C SNP and lung cancer" @default.
• W3032243119 doi "https://doi.org/10.3760/cma.j.issn.1008-6315.2018.03.001" @default.
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