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- W3032247377 abstract "One of the key challenges in current cancer research is the development of computational strategies to support clinicians in the identification of successful personalized treatments. Control theory might be an effective approach to this end, as proven by the long-established application to therapy design and testing. In this respect, we here introduce the Control Theory for Therapy Design (CT4TD) framework, which employs optimal control theory on patient-specific pharmacokinetics (PK) and pharmacodynamics (PD) models, to deliver optimised therapeutic strategies. The definition of personalized PK/PD models allows to explicitly consider the physiological heterogeneity of individuals and to adapt the therapy accordingly, as opposed to standard clinical practices.} CT4TD can be used in two distinct scenarios. At the time of the diagnosis, met{} allows to set optimised personalised administration strategies, aimed at reaching selected target drug concentrations, while minimizing the costs in terms of toxicity and adverse effects. Moreover, if longitudinal data on patients under treatment are available, our approach allows to adjust the ongoing therapy, by relying on simplified models of cancer population dynamics, with the goal of minimising or controlling the tumour burden. CT4TD is highly scalable, as it employs the efficient dCRAB (RedCRAB} optimization algorithm, and the results are robust, as proven by extensive tests on synthetic data. Furthermore, the theoretical framework is general, and it might be applied to any therapy for which a PK/PD model can be estimated, and for any kind of administration and cost. } As a proof of principle, we present the application of CT4TD to Imatinib administration in Chronic Myeloid Leukaemia, in which we adopt a simplified model of cancer population dynamics. In particular, we show that the optimised therapeutic strategies are diversified among patients, and display improvements with respect to the current standard regime." @default.
- W3032247377 created "2020-06-05" @default.
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- W3032247377 date "2020-05-28" @default.
- W3032247377 modified "2023-10-18" @default.
- W3032247377 title "An Optimal Control Framework for the Automated Design of Personalized Cancer Treatments" @default.
- W3032247377 cites W1571271309 @default.
- W3032247377 cites W174227552 @default.
- W3032247377 cites W1748122972 @default.
- W3032247377 cites W1917228087 @default.
- W3032247377 cites W1966653484 @default.
- W3032247377 cites W1977905227 @default.
- W3032247377 cites W1978533437 @default.
- W3032247377 cites W1978821257 @default.
- W3032247377 cites W1987239635 @default.
- W3032247377 cites W1994327535 @default.
- W3032247377 cites W1995583052 @default.
- W3032247377 cites W1995618464 @default.
- W3032247377 cites W2001838945 @default.
- W3032247377 cites W2009795777 @default.
- W3032247377 cites W2019355348 @default.
- W3032247377 cites W2020758257 @default.
- W3032247377 cites W2030615871 @default.
- W3032247377 cites W2030752829 @default.
- W3032247377 cites W2031752336 @default.
- W3032247377 cites W2034074778 @default.
- W3032247377 cites W2034282770 @default.
- W3032247377 cites W2036132399 @default.
- W3032247377 cites W2037401973 @default.
- W3032247377 cites W2040625016 @default.
- W3032247377 cites W2049594435 @default.
- W3032247377 cites W2055515709 @default.
- W3032247377 cites W2056300644 @default.
- W3032247377 cites W2058201897 @default.
- W3032247377 cites W2060085351 @default.
- W3032247377 cites W2060565181 @default.
- W3032247377 cites W2062330442 @default.
- W3032247377 cites W2063669413 @default.
- W3032247377 cites W2064381013 @default.
- W3032247377 cites W2084420473 @default.
- W3032247377 cites W2087039395 @default.
- W3032247377 cites W2092606584 @default.
- W3032247377 cites W2098802717 @default.
- W3032247377 cites W2099473820 @default.
- W3032247377 cites W2103443944 @default.
- W3032247377 cites W2105025199 @default.
- W3032247377 cites W2105214030 @default.
- W3032247377 cites W2107582371 @default.
- W3032247377 cites W2107962575 @default.
- W3032247377 cites W2112942078 @default.
- W3032247377 cites W2121510837 @default.
- W3032247377 cites W2123303153 @default.
- W3032247377 cites W2126928912 @default.
- W3032247377 cites W2135630936 @default.
- W3032247377 cites W2140111850 @default.
- W3032247377 cites W2147641419 @default.
- W3032247377 cites W2154856176 @default.
- W3032247377 cites W2160409148 @default.
- W3032247377 cites W2163329109 @default.
- W3032247377 cites W2166240979 @default.
- W3032247377 cites W2168289672 @default.
- W3032247377 cites W2171074980 @default.
- W3032247377 cites W2179429273 @default.
- W3032247377 cites W2189269974 @default.
- W3032247377 cites W2209688796 @default.
- W3032247377 cites W2253465175 @default.
- W3032247377 cites W2270276547 @default.
- W3032247377 cites W231975775 @default.
- W3032247377 cites W2325281333 @default.
- W3032247377 cites W2526458083 @default.
- W3032247377 cites W2560023695 @default.
- W3032247377 cites W2594744993 @default.
- W3032247377 cites W2632449799 @default.
- W3032247377 cites W2738988147 @default.
- W3032247377 cites W2757676737 @default.
- W3032247377 cites W2770818476 @default.
- W3032247377 cites W2791561208 @default.
- W3032247377 cites W2796042654 @default.
- W3032247377 cites W2802556859 @default.
- W3032247377 cites W2805733506 @default.
- W3032247377 cites W2888094747 @default.
- W3032247377 cites W2889627012 @default.
- W3032247377 cites W2901168740 @default.
- W3032247377 cites W2918794395 @default.
- W3032247377 cites W2948296790 @default.
- W3032247377 cites W2949647620 @default.
- W3032247377 cites W2949814822 @default.
- W3032247377 cites W2949975320 @default.
- W3032247377 cites W2952749566 @default.
- W3032247377 cites W2963787066 @default.
- W3032247377 cites W2967948480 @default.
- W3032247377 cites W2998744531 @default.
- W3032247377 cites W3098360175 @default.