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- W3032249567 abstract "Combined radiation-trauma injury is mainly observed in radiation treatment of cancer and radiation injury with traumatic patients. The prominent problem of combined radiation-trauma injury is delayed or prolonged wound healing. The mechanism of the impaired wound healing is complicated, and the current effective treatment method are limited. This paper reviews the mechanism and treatment of this impaired wound healing, including the cellular depletion, stromal cell dysfunction, aberrant collagen deposition, microvascular damage, as well as the targeted therapies for the impaired wound healing such as stem cell repletion, antioxidant therapy, transforming growth factor beta-1 (TGF-β1) modulation, and implantable biomaterials. This paper is designed to provide a reference for further deep research on the mechanism and treatment of radiation-trauma injury.Key words: Combined radiation trauma; Impaired wound healing; Mechanism; Therapy" @default.
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- W3032249567 date "2018-11-25" @default.
- W3032249567 modified "2023-09-26" @default.
- W3032249567 title "Research progresses in the mechanism and treatment of the impaired wound healing of combined radiation-trauma injury" @default.
- W3032249567 doi "https://doi.org/10.3760/cma.j.issn.0254-5098.2018.11.015" @default.
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