Matches in SemOpenAlex for { <https://semopenalex.org/work/W3032271937> ?p ?o ?g. }
- W3032271937 endingPage "13084" @default.
- W3032271937 startingPage "13072" @default.
- W3032271937 abstract "Islet amyloid polypeptide (IAPP) is a hormone co-secreted with insulin and zinc from pancreatic β-cells. To overcome the low solubility of human IAPP, we characterized zinc complexes species formed with 1) a mutated form of rat-IAPP(1-37; R18 H) able to mimic the human IAPP, 2) the r-IAPP(1-37) and the IAPP(1-8) fragment. Stoichiometry, speciation and coordination features of zinc(II) complexes were unveiled by ESI-MS, potentiometry and NMR measurements combined with DFT and free-energy simulations. Mononuclear species start to form around pH 6; Zn2+ binds both His18 and N-amino terminus in rat-IAPP(1-37; R18 H). The in silico study allows us to assess not only a structured turn compact domain in r-IAPP(1-37) and r-IAPP(1-37; R18 H) featured by a different free energy barrier for the transition from the compact to elongated conformation upon the coordination of Zn2+ , but also to bring into light a coordination shell further stabilized by noncovalent interactions." @default.
- W3032271937 created "2020-06-05" @default.
- W3032271937 creator A5009190426 @default.
- W3032271937 creator A5018162387 @default.
- W3032271937 creator A5043791282 @default.
- W3032271937 creator A5052915971 @default.
- W3032271937 creator A5054614303 @default.
- W3032271937 creator A5061172141 @default.
- W3032271937 creator A5063785576 @default.
- W3032271937 creator A5083516378 @default.
- W3032271937 date "2020-09-18" @default.
- W3032271937 modified "2023-09-26" @default.
- W3032271937 title "Zinc Interactions with a Soluble Mutated Rat Amylin to Mimic Whole Human Amylin: An Experimental and Simulation Approach to Understand Stoichiometry, Speciation and Coordination of the Metal Complexes" @default.
- W3032271937 cites W1259779892 @default.
- W3032271937 cites W1461176522 @default.
- W3032271937 cites W1548279532 @default.
- W3032271937 cites W1588092320 @default.
- W3032271937 cites W1608388154 @default.
- W3032271937 cites W1936543486 @default.
- W3032271937 cites W1964727310 @default.
- W3032271937 cites W1965863026 @default.
- W3032271937 cites W1966078827 @default.
- W3032271937 cites W1971655398 @default.
- W3032271937 cites W1976499671 @default.
- W3032271937 cites W1976597734 @default.
- W3032271937 cites W1976691227 @default.
- W3032271937 cites W1978760666 @default.
- W3032271937 cites W1978852698 @default.
- W3032271937 cites W1980108905 @default.
- W3032271937 cites W1983867780 @default.
- W3032271937 cites W1993121159 @default.
- W3032271937 cites W1995514972 @default.
- W3032271937 cites W2001478550 @default.
- W3032271937 cites W2005670463 @default.
- W3032271937 cites W2006131003 @default.
- W3032271937 cites W2008884445 @default.
- W3032271937 cites W2009675851 @default.
- W3032271937 cites W2010076108 @default.
- W3032271937 cites W2012170675 @default.
- W3032271937 cites W2016399127 @default.
- W3032271937 cites W2019571216 @default.
- W3032271937 cites W2020094531 @default.
- W3032271937 cites W2023145261 @default.
- W3032271937 cites W2024231537 @default.
- W3032271937 cites W2024849831 @default.
- W3032271937 cites W2029514908 @default.
- W3032271937 cites W2035687084 @default.
- W3032271937 cites W2038079486 @default.
- W3032271937 cites W2038438971 @default.
- W3032271937 cites W2041704302 @default.
- W3032271937 cites W2048876720 @default.
- W3032271937 cites W2050124005 @default.
- W3032271937 cites W2053402937 @default.
- W3032271937 cites W2055513218 @default.
- W3032271937 cites W2057806291 @default.
- W3032271937 cites W2059013803 @default.
- W3032271937 cites W2061111679 @default.
- W3032271937 cites W2066812386 @default.
- W3032271937 cites W2068688814 @default.
- W3032271937 cites W2071658446 @default.
- W3032271937 cites W2072886986 @default.
- W3032271937 cites W2080129721 @default.
- W3032271937 cites W2092848270 @default.
- W3032271937 cites W2093289749 @default.
- W3032271937 cites W2094026322 @default.
- W3032271937 cites W2097259690 @default.
- W3032271937 cites W2102769085 @default.
- W3032271937 cites W2103945336 @default.
- W3032271937 cites W2105051532 @default.
- W3032271937 cites W2106885160 @default.
- W3032271937 cites W2112152970 @default.
- W3032271937 cites W2113925646 @default.
- W3032271937 cites W2115168896 @default.
- W3032271937 cites W2117506839 @default.
- W3032271937 cites W2128460405 @default.
- W3032271937 cites W2128592308 @default.
- W3032271937 cites W2138520198 @default.
- W3032271937 cites W2144288821 @default.
- W3032271937 cites W2144481414 @default.
- W3032271937 cites W2145124130 @default.
- W3032271937 cites W2147226356 @default.
- W3032271937 cites W2149655632 @default.
- W3032271937 cites W2158081658 @default.
- W3032271937 cites W2159489160 @default.
- W3032271937 cites W2160731398 @default.
- W3032271937 cites W2165176013 @default.
- W3032271937 cites W2171219272 @default.
- W3032271937 cites W2209140768 @default.
- W3032271937 cites W2272119425 @default.
- W3032271937 cites W2314090118 @default.
- W3032271937 cites W2319288454 @default.
- W3032271937 cites W2331288560 @default.
- W3032271937 cites W2343513399 @default.
- W3032271937 cites W2409583355 @default.
- W3032271937 cites W2468038908 @default.
- W3032271937 cites W2484449611 @default.
- W3032271937 cites W2492402360 @default.
- W3032271937 cites W2523383800 @default.