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- W3032281970 abstract "目的 探讨健康老年人无症状性脑白质损害 (WML)和细胞间黏附分子-1 ( ICAM-1) K469E基因多态性之间的关系.方法利用聚合酶链式反应-限制性片段长度多态性法(PCR-RFLP),对121例WML患者和99名对照组老年人的ICAM-1 K469E基因多态性位点进行检测和分析.结果病例组和对照组ICAM-1 K469E多态性分布符合Hardy-Weinberg遗传平衡定律,说明研究对象具有群体代表性.WML组KK基因型和K等位基因频率均明显高于对照组(基因型50.4% vs 25.3%,P<0.01;等位基因频率73.1% vs 52.0%,P=0.002),两组间差异有统计学意义.Logistic多因素回归分析显示在校正高血压、年龄等因素后,ICAM-1 KK型与WML的发生相关(OR=2.99,P=0.01).和非KK型个体相比,KK型个体患WML相对危险度是前者的2.99倍.结论 ICAM-1KK基因型与WML的发生具有相关性,提示ICAM-1基因K469E多态性可能是中国人WML发病的遗传学危险因素。" @default.
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- W3032281970 date "2005-04-23" @default.
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- W3032281970 title "Association between intercellular adhesion molecule-1 K469E polymorphism and white matter lesions in asymptomatic elderly people" @default.
- W3032281970 doi "https://doi.org/10.3760/j.issn:1006-7876.2005.04.009" @default.
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