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- W3032298040 abstract "目的 观察玻璃体内注射曲安奈德(intravitreal injection of triamcinolone acetonide,IVTA)治疗黄斑水肿后视网膜形态和功能的变化.方法对黄斑水肿的患者35例37只眼经玻璃体内注射曲安奈德后定期随访6月,对比分析治疗前后的最佳矫正视力、光学相干断层扫描、视野检查、眼底荧光造影及眼压的变化情况.统计学方法采用SPSS统计软件进行配伍组设计的两因素方差分析,差异有显著性时用S-N-K法行q检验两两比较,相关因素用Pearson相关分析.结果全部患者IVTA后最佳矫正视力均比术前提高(P＜0.05).OCT测量黄斑区视网膜厚度,IVTA前黄斑区视网膜厚度为(602.53±191.27)μm,IVTA后1、3、6月分别为(271.80±93.77)μm、(207.87±81.88)μm、(273.87±187.17)μm,IVTA前后相比有显著性差异(P＜0.05).复发患者再次IVTA后CMT仍显著降低.在视野检查中,IVTA后1、3、6月黄斑区中心凹阈值均比术前有明显改善;IVTA后平均缺损绝对值较IVTA前减小;IVTA后模式标准差值较IVTA前减小.IVTA前后最佳矫正视力与黄斑区视网膜厚度为显著负相关(P＜0.05),与黄斑中心凹光敏感度呈高度正相关(P＜0.01).结论 IVTA治疗黄斑水肿随访半年,患者中心视力显著提高,黄斑水肿减轻,荧光造影显示黄斑区荧光渗漏减少甚至部分患者无渗漏.黄斑区视网膜厚度显著降低,视网膜光敏感度有显著提高,视野缺损也有所降低,中心暗点减少.IVTA后3～6月出现黄斑水肿复发,再次行IVTA病情仍可有明显改善。" @default.
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- W3032298040 date "2006-01-10" @default.
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- W3032298040 title "Mlacular morphology and functional changes after intravitreal triamcinolone acetonide for macular edema" @default.
- W3032298040 doi "https://doi.org/10.3760/cma.j.issn.1006-4443.2006.01.004" @default.
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