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- W3032301091 abstract "ObjectiveTo investigate the synergistic effect of regorafenib and verteporfin in hepatocellular carcinoma cells.MethodsCell counting kit-8 (CCK-8) assay was used to detect the cytotoxicity of regorafenib and the combination of regorafenib and verteporfin. Transwell migration assay was used to detect cell migration ability of regorafenib and the combination of regorafenib and verteporfin. Western blotting was used to evaluate epithelial-mesenchymal transition (EMT) related protein of regorafenib and the combination of regorafenib and verteporfin. Flow cytometry was used to detected cell apoptosis of regorafenib and the combination of regorafenib and verteporfin.ResultsCCK-8 assay showed that the half maximal inhibitory concentration (IC50) of regorafenib was 3.576 μmol/L, and decreased to 2.629 μmol/L when regorafenib was combined with 1 μmol/L verteporfin. Transwell invasion assay showed that the membrane number of the cells treated with 4 μmol/L regorafenib and 2 μmol/L verteporfin was (147.00±9.54), lower than the membrane number of the cells treated with 4 μmol/L regorafenib (336.00±27.31; t=-11.360, P=0.000), and significantly lower than the membrane number in control group (531.67±29.54; t=-21.466, P=0.000). The percentage of apoptotic cells treated with 1 μmol/L verteporfin and 2 μmol/L regorafenib was (10.20±1.06)%, higher than the percentage of apoptotic cells treated with 2 μmol/L regorafenib [(5.13±0.95)%; t=6.170, P=0.004], significantly higher than the percentage of apoptotic cells in control group [(1.13±0.35)%; t=14.080, P=0.000].ConclusionVerteporfin can enhance the effects of regorafenib on inhibiting proliferation and migration of hepatocellular carcinoma cells and promote the apoptosis of hepatocellular carcinoma cells.Key words: Hepatocellular carcinoma; Verteporfin; Regorafenib" @default.
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- W3032301091 date "2017-12-08" @default.
- W3032301091 modified "2023-09-23" @default.
- W3032301091 title "Synergistic effect of regorafenib and verteporfin in hepatocellular carcinoma cells" @default.
- W3032301091 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2017.12.030" @default.
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