Matches in SemOpenAlex for { <https://semopenalex.org/work/W3032305134> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W3032305134 endingPage "552" @default.
- W3032305134 startingPage "549" @default.
- W3032305134 abstract "Objective To determine the in vitro antifungal effects of closantel against Candida albicans.Methods A microdilution method was used to determine the minimum inhibitory concentration (MIC)of fluconazole alone and in combination with closantel against Candida albicans standard strain CAF-2.Ten strains of Candida albicans were cultured in RPMI-1640 liquid culture containing 10％ calf serum with or without the presence of closantel at 16 mg/L,followed by the observation of hypha formation.Transmission electron microscopy (TEM) and scanning electron microscopy (SEM) were performed to observe the ultrastructure of Candida albicans CAF-2 strain after exposure to closantel at 16 mg/L for 24 hours.Results Closantel could inhibit the growth of Candida albicans,and enhance the antifungal effect of fluconazole against Candida albicans in vitro.The percentage of Candida albicans forming hypha was 91.2％ ± 3.9％ in untreated Candida albicans,significantly higher than that in closantel-treated Candida albicans (29.8％ ± 5.1％,t =30.24,P ＜ 0.05).As TEM showed,closantel-treated Candida albicans gave a round,oval or pleomorphic appearance,with an irregular budding from the cell surface.Further more,the electron dense layer in the outer layer of cell wall was absent or unevenly distributed,the transparent layer was irregularly thickened,some cell membrane was locally disrupted or collapsed,and intracellular vacuoles increased after closantel treatment.Scanning microscopy revealed a rough surface,sparse and irregular budding of Candida albicans after treatment with closantel.Conclusion Closantel exhibits a promising anti-Candida albicans property in vitro.Key words: Candida albicans; Microbial sensitivity tests; Closantel; Microscopy, electron" @default.
- W3032305134 created "2020-06-05" @default.
- W3032305134 creator A5012568385 @default.
- W3032305134 date "2012-08-15" @default.
- W3032305134 modified "2023-09-23" @default.
- W3032305134 title "In vitro antifungal activity of closantel against Candida albicans" @default.
- W3032305134 doi "https://doi.org/10.3760/cma.j.issn.0412-4030.2012.08.006" @default.
- W3032305134 hasPublicationYear "2012" @default.
- W3032305134 type Work @default.
- W3032305134 sameAs 3032305134 @default.
- W3032305134 citedByCount "0" @default.
- W3032305134 crossrefType "journal-article" @default.
- W3032305134 hasAuthorship W3032305134A5012568385 @default.
- W3032305134 hasConcept C145081991 @default.
- W3032305134 hasConcept C185592680 @default.
- W3032305134 hasConcept C202751555 @default.
- W3032305134 hasConcept C2779548794 @default.
- W3032305134 hasConcept C2780651595 @default.
- W3032305134 hasConcept C2780917455 @default.
- W3032305134 hasConcept C55493867 @default.
- W3032305134 hasConcept C86803240 @default.
- W3032305134 hasConcept C89423630 @default.
- W3032305134 hasConcept C90080823 @default.
- W3032305134 hasConceptScore W3032305134C145081991 @default.
- W3032305134 hasConceptScore W3032305134C185592680 @default.
- W3032305134 hasConceptScore W3032305134C202751555 @default.
- W3032305134 hasConceptScore W3032305134C2779548794 @default.
- W3032305134 hasConceptScore W3032305134C2780651595 @default.
- W3032305134 hasConceptScore W3032305134C2780917455 @default.
- W3032305134 hasConceptScore W3032305134C55493867 @default.
- W3032305134 hasConceptScore W3032305134C86803240 @default.
- W3032305134 hasConceptScore W3032305134C89423630 @default.
- W3032305134 hasConceptScore W3032305134C90080823 @default.
- W3032305134 hasIssue "08" @default.
- W3032305134 hasLocation W30323051341 @default.
- W3032305134 hasOpenAccess W3032305134 @default.
- W3032305134 hasPrimaryLocation W30323051341 @default.
- W3032305134 hasRelatedWork W1979163285 @default.
- W3032305134 hasRelatedWork W2016768243 @default.
- W3032305134 hasRelatedWork W2028352278 @default.
- W3032305134 hasRelatedWork W2054136339 @default.
- W3032305134 hasRelatedWork W2166202592 @default.
- W3032305134 hasRelatedWork W2314314753 @default.
- W3032305134 hasRelatedWork W2368813915 @default.
- W3032305134 hasRelatedWork W2372934758 @default.
- W3032305134 hasRelatedWork W2377407755 @default.
- W3032305134 hasRelatedWork W2379727119 @default.
- W3032305134 hasRelatedWork W2386933060 @default.
- W3032305134 hasRelatedWork W2403361153 @default.
- W3032305134 hasRelatedWork W2404824196 @default.
- W3032305134 hasRelatedWork W2417937475 @default.
- W3032305134 hasRelatedWork W2498487781 @default.
- W3032305134 hasRelatedWork W2755603749 @default.
- W3032305134 hasRelatedWork W2912396408 @default.
- W3032305134 hasRelatedWork W3029880179 @default.
- W3032305134 hasRelatedWork W3091157425 @default.
- W3032305134 hasRelatedWork W3031240532 @default.
- W3032305134 hasVolume "45" @default.
- W3032305134 isParatext "false" @default.
- W3032305134 isRetracted "false" @default.
- W3032305134 magId "3032305134" @default.
- W3032305134 workType "article" @default.