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- W3032312536 abstract "ObjectiveTo determine the fetal facial angles at 11-38 weeks of gestation by three-dimensional ultrasound (3DUS) and analyze the correlation between facial angles and gestational age(GA).MethodsFrom 2013 April to 2014 February, 439 singleton fetuses ranged 11-38 weeks of gestation were enrolled in this study. The details of mid-sagittal plane of facial profile was confirmed with 3DUS. Four facial angels were measured in this plane, including frontomaxillary facial angle(FMF), frontonasal angle(FNA), mandibulomaxillary facial angle(MMF) and maxilla-nasion-mandible angle(MNM). The intra- and interobserver reliability were calculated in first 30 cases, intra-class correlation coefficient(ICC) greater than 0.75 indicated good reliability. Pearson′s correlation coefficient(r), curve estimation and polynomial regression models were used to evaluate the correlation of the fetal facial angles with GA.ResultsICC of the same observer were 0.968, 0.962, 0.974 and 0.988, respectively. ICC of different observer were 0.948, 0.905, 0.874 and 0.889, respectively. The fetal facial angles of FMF, FNA, MMF and MNM showed correlations with GA(r=-0.369, 0.447, -0.470, 0.386; all P=0.000). Using GA as the independent variable and the facial angles as the dependent variables, the best fit regressing equation was cubic polynomial: FMF=135.300-6.473×GA+ 0.235×GA2-0.003×GA3(R2=0.240, P=0.000); FNA=58.920+ 7.452×GA-0.274×GA2-0.003×GA3(R2=0.297, P=0.000); MMF=132.329-5.337×GA+ 0.191×GA2-0.002×GA3(R2=0.304, P=0.000); MNM=-24.592+ 4.653×GA-0.173×GA2+ 0.002×GA3(R2=0.413, P=0.000).ConclusionsThe development of fetal facial angles are related to GA. The growing patterns of fetal facial angles fit with a cubic polynomial function.Key words: Ultrasonography; Fetus; Gestational age; Facial angle" @default.
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- W3032312536 date "2019-04-25" @default.
- W3032312536 modified "2023-09-30" @default.
- W3032312536 title "Correlation and regression analysis of fetal facial angles at 11-38 weeks of pregnancy with gestational age" @default.
- W3032312536 doi "https://doi.org/10.3760/cma.j.issn.1004-4477.2019.04.006" @default.
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