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- W3032313638 abstract "ObjectiveTo explore the association between gastric cancer and genetic polymorphism of HLA-DRB1 and HLA-DQB1.MethodsPolymerase chain reaction sequence specific primer(PCR-SSP) was applied to analyze HLA-DRB1 and HLA-DQB1 genotypes in 38 patients with gastric cancer Hardy-Weinberg balance was tested 200 healthy people were collected as control group.The difference between the two groups in frequency of genes was analyzed.ResultsThe gene distribution of HLA-DRB1 and HLA-DQB1 was consistent with hereditary rules(P>0.05). The gene frequency of HLA-DRB1*09 was significantly lower(P<0.05) than that in control group.There were no significant differences in the rest of gene loci between experimental group and control group.ConclusionHLA DRB1*09 may be the inhibiting gene of gastric cancer.Key words: Gastric cancer; HLA-DRB1; HLA-DQB1" @default.
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- W3032313638 date "2015-09-05" @default.
- W3032313638 modified "2023-09-26" @default.
- W3032313638 title "The association between gastric cancer and genetic polymorphism of HLA-DRB1 and HLA-DQB1" @default.
- W3032313638 doi "https://doi.org/10.3760/cma.j.issn.1673-4394.2015.05.005" @default.
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