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- W3032314458 abstract "Objective To assess the effect of parenteral (PN) glutamine supplementation on gut function in the very low birth weight infants(VLBWIs). Methods A muhicentered, randomized, double-blinded, clinical trial was conducted. Thirty VLBWIs (<1500 g at birth) at two children's medical centers were randomly and equally assigned to either control group [sPN; amino acid was given at the dosage recommended by Chinese guidelines for the use of nutritional support in critically ill neonates(Jun. 2006)] or glutamine-supplemented group [GInPN; glutamine intake, 0. 3 g/(kg · d)]. The primary endpoints were the time to achieve full enteral nutrition, the incidence of gastric residuals, duration of parenteral nutrition and mortality. Results There were no significant differences between GInPN and sPN group in the time to achieve full enteral nutrition [(20±6)d vs (21±9)d], the number of gastric residuals [(3±4) vs (1±2)] and duration of parenteral nutrition [(17±7)d vs (17±8)d]. Of the 15 infants in the GlnPN group, 2 dropped out and 4 suspended treatment, and 4 in the control group suspended treatment (intention-to-treat analysis showed RR= 1.182; 95%CI:0. 937-1. 490). Conclusions Parenteral glutamine supplementation can not shorten the time to achieve full enteral nutrition and duration of parenteral nutrition, or reduce the incidence of gastric residuals and mortality in VLBWIs.Key words: Parenteral nutrition; Glutamine; Infant,very low birth weight" @default.
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- W3032314458 date "2008-07-16" @default.
- W3032314458 modified "2023-09-23" @default.
- W3032314458 title "Effect of parenteral glutamine supplementation on gut function in very low birth weight infants" @default.
- W3032314458 doi "https://doi.org/10.3760/cma.j.issn.1007-9408.2008.04.011" @default.
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