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- W3032319315 abstract "Objective To investigate the expression of Toll-like receptor 4 (TLR4) and inflammatory cytokines such as interleukin (IL)-1β,IL-6 and tumor necrosis factor (TNF)-α,and explore the modulatory effect of TLR4 on inflammatory cytokines following fluid percussion brain injury in rats.Methods The experimental models were established in 48 adult rats.The water content of edematous brain and the expression of TLR4,IL-1β,IL-6 and TNF-α were measured with dry-wet measure,and immunohistochemistry at 6,12,24 h,3 day,and 7 day after operation respectively.Results As compared with shamoperated group,the water content of edematous brain was increased in traumatic brain injury (TBI) group from 6 h [(78.86 ± 0.54) ％] to the maximum at 24 h [(83.07 ± 0.27) ％],and gradually decreased at 3 day [(81.85 ± 1.26)％].TLR4,IL-6,IL-1β and TNF-α immunoreactive expression was increased from 6 h (1.50 ± 0.58,3.75 ± 0.48,3.50 ± 0.58,and 5.75 ± 2.36 respectively) to the maximum at 12 h or 24 h (5.50 ± 1.00,7.80 ± 1.64,7.75 ± 1.05,and 7.50 ± 1.73 respectively),lasted to the 3rd day,and began to drop at 7th day.The linear regression analysis indicated that TLR4 expression had positive correlations with expression of IL-1 β,IL-6 and TNF-α (r =0.941,r =0.907,r =0.836 respectively,P ＜ 0.05).Conclusion TLR4,IL-6,IL-1β and TNF-α expression is upregulated following fluid percussion injury in rats,and TLR4 is involved in secondary brain injury by mediating inflammatory cytokines.Key words: Toll-like receptor 4; Inflammatory cytokine; Brain injury; Fluid percussion" @default.
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- W3032319315 date "2014-09-08" @default.
- W3032319315 modified "2023-09-24" @default.
- W3032319315 title "The modulatory effect of Toll-like receptor 4 on inflammatory cytokines following fluid percussion brain injury in rats" @default.
- W3032319315 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2014.09.020" @default.
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