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- W3032322611 abstract "目的 观察高压氧暴露后小鼠肺组织巨噬细胞炎症蛋白-2(macrophage inflammatory protein-2,MIP-2)mRNA表达的影响.方法 40只健康C57BL/6雄性小鼠采用随机数字法分为5组:650 UPTD组、850 UPTD组、1100 UPTD组、高压常氧组和对照组.小鼠在密闭氧舱中吸入高压纯氧建立肺型氧中毒模型.对照组吸入空气,高压常氧组吸入氮氧混合气,氧分压与空气中氧分压相同.动物出舱后解剖取肺,肺组织用于病理检测和RT-PCR方法检测MIP-2 mRNA的表达.结果 (1)高压氧暴露组与对照组相比,MIP-2 mRNA表达明显增高(P＜0.05);(2)高压常氧组与对照组MIP-2 mRNA表达没有明显变化(P＞0.05).结论 随着高压氧暴露剂量的增加,MIP-2 mRNA的表达明显增多,并且炎症损伤也呈增加趋势。" @default.
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- W3032322611 date "2006-08-28" @default.
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- W3032322611 title "Changes of macrophage inflammatory protein-2 mRNA expression in the lung tissue of pulmonary oxygen toxicity mice" @default.
- W3032322611 doi "https://doi.org/10.3760/cma.j.issn.1009-6906.2006.04.014" @default.
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