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- W3032326246 abstract "Objective To detect IL-17 level of bone marrow in patients with multiple myeloma bone disease,and to investigate its clinical significance.Methods The bone marrow IL-17 levels were quantified in 33 cases of multiple myeloma patients and 20 normal control by ELISA assay. RANKL mRNA expression were detected by using RT-PCR.Results In bone marrow supernatant,IL-17 was detected in both groups,and RANKL mRNA were detected in both groups too. IL-17 and RANKL mRNA levels in bone marrow of patients with MM were significantly higher than those in the control group (P＜0.05). The bone marrow concentrations of IL-17 and bone marrow mononuclear cells' RANKL mRNA expression in active stage were significantly higher than those in stable stage (P＜0.05).The bone marrow IL-17 and RANKL were significantly correlated (r =690,P＜0.05).Conclusion IL-17 may play an important role in the pathogenesis of MM.Key words: Multiple myeloma bone disease; Interleukin-17; Receptor activator of nuclear factor-kappaB" @default.
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- W3032326246 date "2012-05-25" @default.
- W3032326246 modified "2023-09-25" @default.
- W3032326246 title "Expression and significance of IL-17 in multiple myeloma bone disease" @default.
- W3032326246 doi "https://doi.org/10.3760/cma.j.issn.1009-9921.2012.05.007" @default.
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