Matches in SemOpenAlex for { <https://semopenalex.org/work/W3032357014> ?p ?o ?g. }
- W3032357014 endingPage "107677" @default.
- W3032357014 startingPage "107677" @default.
- W3032357014 abstract "Cell polarity is essential for the architecture and function of numerous epithelial tissues. Here, we show that apical restriction of planar cell polarity (PCP) components is necessary for the maintenance of epithelial integrity. Using the mammalian pancreas as a model, we find that components of the core PCP pathway, such as the transmembrane protein Van Gogh-like (VANGL), become apically restricted over a period of several days. Expansion of VANGL localization to the basolateral membranes of progenitors leads to their death and disruption of the epithelial integrity. VANGL basolateral expansion does not affect apico-basal polarity but acts in the cells where Vangl is mislocalized by reducing Dishevelled and its downstream target ROCK. This reduction in ROCK activity culminates in progenitor cell egression, death, and eventually pancreatic hypoplasia. Thus, precise spatiotemporal modulation of VANGL-dependent PCP signaling is crucial for proper pancreatic morphogenesis." @default.
- W3032357014 created "2020-06-05" @default.
- W3032357014 creator A5006795778 @default.
- W3032357014 creator A5016188394 @default.
- W3032357014 creator A5016422339 @default.
- W3032357014 creator A5053495852 @default.
- W3032357014 creator A5056329949 @default.
- W3032357014 creator A5088989729 @default.
- W3032357014 date "2020-05-01" @default.
- W3032357014 modified "2023-09-30" @default.
- W3032357014 title "Apical Restriction of the Planar Cell Polarity Component VANGL in Pancreatic Ducts Is Required to Maintain Epithelial Integrity" @default.
- W3032357014 cites W106359550 @default.
- W3032357014 cites W114458954 @default.
- W3032357014 cites W1795445644 @default.
- W3032357014 cites W1966032423 @default.
- W3032357014 cites W1968137237 @default.
- W3032357014 cites W1978228542 @default.
- W3032357014 cites W1978789471 @default.
- W3032357014 cites W1980487066 @default.
- W3032357014 cites W1987644757 @default.
- W3032357014 cites W1988977149 @default.
- W3032357014 cites W1992644684 @default.
- W3032357014 cites W1996021785 @default.
- W3032357014 cites W1996468220 @default.
- W3032357014 cites W2011505059 @default.
- W3032357014 cites W2022798578 @default.
- W3032357014 cites W2028236271 @default.
- W3032357014 cites W2030029307 @default.
- W3032357014 cites W2030833624 @default.
- W3032357014 cites W2031878176 @default.
- W3032357014 cites W2035723694 @default.
- W3032357014 cites W2037850388 @default.
- W3032357014 cites W2039117468 @default.
- W3032357014 cites W2041148711 @default.
- W3032357014 cites W2044638670 @default.
- W3032357014 cites W2044764655 @default.
- W3032357014 cites W2046518908 @default.
- W3032357014 cites W2047586015 @default.
- W3032357014 cites W2047656863 @default.
- W3032357014 cites W2055557491 @default.
- W3032357014 cites W2066135299 @default.
- W3032357014 cites W2067149878 @default.
- W3032357014 cites W2069066935 @default.
- W3032357014 cites W2070050569 @default.
- W3032357014 cites W2070830862 @default.
- W3032357014 cites W2077911326 @default.
- W3032357014 cites W2089688272 @default.
- W3032357014 cites W2102864788 @default.
- W3032357014 cites W2103391067 @default.
- W3032357014 cites W2104284856 @default.
- W3032357014 cites W2108056400 @default.
- W3032357014 cites W2109017100 @default.
- W3032357014 cites W2111760008 @default.
- W3032357014 cites W2116475082 @default.
- W3032357014 cites W2119040073 @default.
- W3032357014 cites W2119906258 @default.
- W3032357014 cites W2120983879 @default.
- W3032357014 cites W2126624378 @default.
- W3032357014 cites W2129612653 @default.
- W3032357014 cites W2130200732 @default.
- W3032357014 cites W2130495524 @default.
- W3032357014 cites W2133172561 @default.
- W3032357014 cites W2136032801 @default.
- W3032357014 cites W2136625706 @default.
- W3032357014 cites W2137518600 @default.
- W3032357014 cites W2140883347 @default.
- W3032357014 cites W2146916662 @default.
- W3032357014 cites W2150589615 @default.
- W3032357014 cites W2150671475 @default.
- W3032357014 cites W2153803455 @default.
- W3032357014 cites W2154799239 @default.
- W3032357014 cites W2163226407 @default.
- W3032357014 cites W2165015044 @default.
- W3032357014 cites W2167279371 @default.
- W3032357014 cites W2170185182 @default.
- W3032357014 cites W2191669718 @default.
- W3032357014 cites W2268692103 @default.
- W3032357014 cites W2302317616 @default.
- W3032357014 cites W2414259989 @default.
- W3032357014 cites W2469756446 @default.
- W3032357014 cites W2525290462 @default.
- W3032357014 cites W2560304181 @default.
- W3032357014 cites W2564039928 @default.
- W3032357014 cites W2576205103 @default.
- W3032357014 cites W2586004317 @default.
- W3032357014 cites W2594717863 @default.
- W3032357014 cites W2597304242 @default.
- W3032357014 cites W2599641104 @default.
- W3032357014 cites W2599684899 @default.
- W3032357014 cites W2612535031 @default.
- W3032357014 cites W2736027624 @default.
- W3032357014 cites W2755419006 @default.
- W3032357014 cites W2762979732 @default.
- W3032357014 cites W2765642278 @default.
- W3032357014 cites W2765676808 @default.
- W3032357014 cites W2770567999 @default.
- W3032357014 cites W2789973757 @default.
- W3032357014 cites W2791428099 @default.