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- W3032358772 abstract "ObjectiveTo investigate the efficacy of midazolam combined with remifentanil in treatment of spasm in adult patients with tetanus.MethodsA total of 22 cases of adult tetanus patients treated from July 2012 to November 2015 were enrolled in the study. The patients were treated by continuous micro pump infusion of midazolam combined with remifentanil for sedation and analgesia. The changes of vital signs, the frequency and duration of spasm, the Ramsay sedation score and the size of mouth opening were observed before and after treatment.ResultsAll patients were treated for an average (13.5±3.2)days, mean Ramsay sedation score (3.2±1.3)points. Compared with before and after treatment, the seizure frequency was significantly reduced, the duration was significantly shorter, and the mouth opening was increased gradually (P>0.05). Decreased blood pressure and heart rate were significantly decreased (P 0.05 ). All patients were cured. There was not any severe complication or death in this study.ConclusionA continuous intravenous infusion of midazolam combined with remifentanil, under a strict monitoring, provides a safe and effective method on the spasm control treatment for tetanus patients. Rational use of this treatment can achieve an ideal sedation, analgesia and spasm control effect.Key words: Tetanus; Midazolam; Remifentanil; Spasm; Sedation" @default.
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- W3032358772 date "2017-02-18" @default.
- W3032358772 modified "2023-09-26" @default.
- W3032358772 title "Efficacy of midazolam combined with remifentanil in control of spasm in patients with tetanus" @default.
- W3032358772 doi "https://doi.org/10.3877/cma.j.issn.2095-9133.2017.01.005" @default.
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