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• W3032360571 abstract "Abstract Glaucoma is the leading cause of irreversible vision loss. Ocular hypertension is a major risk factor for glaucoma and recent work has demonstrated critical early neuroinflammatory insults occur in the optic nerve head following ocular hypertension. Microglia and infiltrating monocytes are likely candidates to drive these neuroinflammatory insults. However, the exact molecular identity / transcriptomic profile of microglia following ocular hypertensive insults is unknown. To elucidate the molecular identity of microglia after long-term exposure to ocular hypertension, we used a mouse model of glaucoma (DBA/2 J). We performed RNA-sequencing of microglia mRNA from the optic nerve head at a time point following ocular hypertensive insults, but preceding detectable neurodegeneration (with microglia identified as being CD45 lo /CD11b + /CD11c − ). Furthermore, RNA-sequencing was performed on optic nerve head microglia from mice treated with radiation therapy, a potent therapy preventing neuroinflammatory insults. Transcriptomic profiling of optic nerve head microglia mRNA identifies metabolic priming with marked changes in mitochondrial gene expression, and changes to phagocytosis, inflammatory, and sensome pathways. The data predict that many functions of microglia that help maintain tissue homeostasis are affected. Comparative analysis of these data with data from previously published whole optic nerve head tissue or monocyte-only samples from DBA/2 J mice demonstrate that many of the neuroinflammatory signatures in these data sets arise from infiltrating monocytes and not reactive microglia. Finally, our data demonstrate that prophylactic radiation therapy of DBA/2 J mice potently abolishes these microglia metabolic transcriptomic changes at the same time points. Together, our data provide a unique resource for the community to help drive further hypothesis generation and testing in glaucoma." @default.
• W3032360571 created "2020-06-05" @default.
• W3032360571 creator A5009710952 @default.
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• W3032360571 date "2020-05-25" @default.
• W3032360571 modified "2023-10-06" @default.
• W3032360571 title "Ocular hypertension suppresses homeostatic gene expression in optic nerve head microglia of DBA/2 J mice" @default.
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• W3032360571 doi "https://doi.org/10.1186/s13041-020-00603-7" @default.
• W3032360571 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7249412" @default.
• W3032360571 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32450896" @default.
• W3032360571 hasPublicationYear "2020" @default.
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