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- W3032368799 abstract "Objective To explore the changes of gene expression profile during differentiation of marrow mesenchymal stem cells (MSCs) towards chondrocytes.Methods The differentiation of human MSCs towards chondrocytes was induced in vitro and the changes of gene expression profiling were examined by using Affymetrix microarray.The differentially expression genes were confirmed by using real-time polymerase chain reaction (real-time PCR).Results Multiple genes showed differential expression on the 7th day and/or 14th day,including the genes encoding extracellular matrix molecule,metalloproteases,cell eycle,development,growth factors and chemokines.The changed genes were involved in cells proliferation,differentiation and development in the early stage (0-7 day),and in cell metabolism and maintenance chondrocyte phenotype in the late stage (7-14 day).Real-time PCR identified that SPARC,CCL25 and CCL4 were significantly up-regulated on the 7th day,and matrix metalloproteinase-11 (MMP-11),tissue inhibitor of metalloproteinase-3 (TIMP-3) and tumor necrosis factor receptor-associated factor 5 (TRAF5) reached the peak expression on the 14th day.These differentially expressed gene could be classified as early markers and late markers in differentiation of MSCs towards chondrocytes in vitro.Conclusion The changes in microenvironmental molecular network involved in regulation of the differentiation of MSCs towards chondrocytes.Key words: Mesenchymal stem cells; Chondrocytes; Differentiation; Microarray" @default.
- W3032368799 created "2020-06-05" @default.
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- W3032368799 date "2013-07-08" @default.
- W3032368799 modified "2023-09-23" @default.
- W3032368799 title "The changes of gene expression profile during differentiation of marrow mesenchymal stem cells towards chondrocytes" @default.
- W3032368799 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2013.07.013" @default.
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