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- W3032377533 abstract "ObjectiveTo study the relationship between Alzheimer's disease(AD)and non-verbal listening comprehension obstacle, and to observe the different specific performance of AD patients in the non-verbal listening comprehension tests involving music and non-verbal semantics, in order to identify the value of these tests in the differential diagnosis of AD.MethodsThe internalized 104 subjects meeting inclusion and exclusion criteria were divided into 4 groups of normal group(n=24), a-MCI group(amnesia-mild cognitive impairment, n=30), mild-AD group(n=27)and moderate AD group(n=23). All subjects received a series of central non-verbal listening comprehension tests which were scored and evaluated, including categorizing and naming according to the sound which involved the non-verbal semantic aspect, judging the emotion and rhythm according to the melody which involved the music aspect.Then the scores were analyzed.Mini-mental state examination(MMSE)and Montreal cognitive assessment(MoCA)were used for assessing the degrees of cognitive impairment.ResultsAll test scores had a positive moderate to high correlations with MMSE and MoCA(all r>0.4, P<0.01), in which sound classification and nomination had better positive correlations than other tests.The statistically significant differences were found in all tests among the four groups(all P<0.05). There was a significant difference in sound nomination between a-MCI group and normal group(P< 0.05). There were significant differences in sound classification, nomination and judging melody rhythm between mild AD group and normal group or a-MCI group(both P<0.05). There were significant differences in all tests between moderate AD group and normal group or a-MCI group(both P<0.05). The sound classification tests, especially sound nomination tests, had better diagnostic value than the rhythm and emotion judgment tests for identifying AD.ConclusionsPatients with AD, even with a-MCI, can develop the non-verbal listening comprehension obstacle, which is aggravated along with the exacerbation of cognitive impairment.AD patient's semantic aspect-involving non-verbal listening ability degeneration is faster than involving the music aspect.Non-verbal listening comprehension tests involving non-verbal semantic aspect, especially sound nomination tests, have better diagnostic values.Key words: Alzheimer's disease; Comprehension; Listening comprehension obstacle" @default.
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- W3032377533 date "2019-01-14" @default.
- W3032377533 modified "2023-09-27" @default.
- W3032377533 title "Relationship between Alzheimer's disease and non-verbal listening comprehension obstacle" @default.
- W3032377533 doi "https://doi.org/10.3760/cma.j.issn.0254-9026.2019.01.006" @default.
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