Matches in SemOpenAlex for { <https://semopenalex.org/work/W3032391330> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W3032391330 endingPage "43" @default.
- W3032391330 startingPage "41" @default.
- W3032391330 abstract "Lipotoxicity can inhibit the expression of pancreatic duodenal homeobox-1 (PDX-1) and mammalian homologue of avian (MafA),so it can reduce the insulin gene expression.Lipotoxicity also can impair insulin secretion of β-cell by upregulating the expression of sterol regulatory element-binding protein1c(SREBP-1c) and activing the target gene.Moreover lipotoxicity can increase the β-cell apoptosis by inducing oxidative stress,imbalance of apoptotic factor,endoplasmic reticulum stress and microRNA pathway.Key words: Lipotoxicity ; Type 2 diabetes mellitus ; Free fatty acids ; β-cell function ; Lipoapoptosis ;" @default.
- W3032391330 created "2020-06-05" @default.
- W3032391330 creator A5026848585 @default.
- W3032391330 creator A5035088458 @default.
- W3032391330 creator A5054833508 @default.
- W3032391330 date "2010-01-20" @default.
- W3032391330 modified "2023-10-18" @default.
- W3032391330 title "Mechanisms of pancreatic β-cell failure induced by lipotoxicity" @default.
- W3032391330 doi "https://doi.org/10.3760/cma.j.issn.1673-4157.2010.01.013" @default.
- W3032391330 hasPublicationYear "2010" @default.
- W3032391330 type Work @default.
- W3032391330 sameAs 3032391330 @default.
- W3032391330 citedByCount "0" @default.
- W3032391330 crossrefType "journal-article" @default.
- W3032391330 hasAuthorship W3032391330A5026848585 @default.
- W3032391330 hasAuthorship W3032391330A5035088458 @default.
- W3032391330 hasAuthorship W3032391330A5054833508 @default.
- W3032391330 hasConcept C126322002 @default.
- W3032391330 hasConcept C134018914 @default.
- W3032391330 hasConcept C139447449 @default.
- W3032391330 hasConcept C158617107 @default.
- W3032391330 hasConcept C190283241 @default.
- W3032391330 hasConcept C2776151105 @default.
- W3032391330 hasConcept C2777391703 @default.
- W3032391330 hasConcept C2778163477 @default.
- W3032391330 hasConcept C2778718757 @default.
- W3032391330 hasConcept C2779306644 @default.
- W3032391330 hasConcept C44353895 @default.
- W3032391330 hasConcept C55493867 @default.
- W3032391330 hasConcept C71924100 @default.
- W3032391330 hasConcept C85051948 @default.
- W3032391330 hasConcept C86803240 @default.
- W3032391330 hasConcept C95444343 @default.
- W3032391330 hasConcept C98335778 @default.
- W3032391330 hasConceptScore W3032391330C126322002 @default.
- W3032391330 hasConceptScore W3032391330C134018914 @default.
- W3032391330 hasConceptScore W3032391330C139447449 @default.
- W3032391330 hasConceptScore W3032391330C158617107 @default.
- W3032391330 hasConceptScore W3032391330C190283241 @default.
- W3032391330 hasConceptScore W3032391330C2776151105 @default.
- W3032391330 hasConceptScore W3032391330C2777391703 @default.
- W3032391330 hasConceptScore W3032391330C2778163477 @default.
- W3032391330 hasConceptScore W3032391330C2778718757 @default.
- W3032391330 hasConceptScore W3032391330C2779306644 @default.
- W3032391330 hasConceptScore W3032391330C44353895 @default.
- W3032391330 hasConceptScore W3032391330C55493867 @default.
- W3032391330 hasConceptScore W3032391330C71924100 @default.
- W3032391330 hasConceptScore W3032391330C85051948 @default.
- W3032391330 hasConceptScore W3032391330C86803240 @default.
- W3032391330 hasConceptScore W3032391330C95444343 @default.
- W3032391330 hasConceptScore W3032391330C98335778 @default.
- W3032391330 hasIssue "01" @default.
- W3032391330 hasLocation W30323913301 @default.
- W3032391330 hasOpenAccess W3032391330 @default.
- W3032391330 hasPrimaryLocation W30323913301 @default.
- W3032391330 hasRelatedWork W12056001 @default.
- W3032391330 hasRelatedWork W178638436 @default.
- W3032391330 hasRelatedWork W1974982135 @default.
- W3032391330 hasRelatedWork W2013907512 @default.
- W3032391330 hasRelatedWork W2013986465 @default.
- W3032391330 hasRelatedWork W2040921297 @default.
- W3032391330 hasRelatedWork W2080660992 @default.
- W3032391330 hasRelatedWork W2099696143 @default.
- W3032391330 hasRelatedWork W2506865341 @default.
- W3032391330 hasRelatedWork W2620572318 @default.
- W3032391330 hasRelatedWork W2623056842 @default.
- W3032391330 hasRelatedWork W2790015849 @default.
- W3032391330 hasRelatedWork W2803576841 @default.
- W3032391330 hasRelatedWork W2936773722 @default.
- W3032391330 hasRelatedWork W2946510606 @default.
- W3032391330 hasRelatedWork W2980342819 @default.
- W3032391330 hasRelatedWork W3032447368 @default.
- W3032391330 hasRelatedWork W3040853231 @default.
- W3032391330 hasRelatedWork W3138370909 @default.
- W3032391330 hasRelatedWork W3162809296 @default.
- W3032391330 hasVolume "30" @default.
- W3032391330 isParatext "false" @default.
- W3032391330 isRetracted "false" @default.
- W3032391330 magId "3032391330" @default.
- W3032391330 workType "article" @default.