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- W3032399560 abstract "目的: 探讨bcl-2基因调控作用与细胞凋亡在神经母细胞瘤(NB)发生发展中的作用. 方法: 应用LSAB免疫组化及TUNEL技术检测NB中bcl-2蛋白表达和细胞凋亡.结果: 17例NB均有bcl-2蛋白表达阳性细胞及凋亡细胞, 表达指数(BEI)9.8%～61.8%, 凋亡指数(AI)20‰～167‰, 二者呈负相关. 年龄?岁、Ⅰ～Ⅱ及Ⅳ-S期、 FH型NB的BEI低于年龄≥1岁、Ⅲ～Ⅳ期及UH型,但差异无显著性意义. AI在不同分组间差异有显著性意义, 且AI与术后生存时间呈正相关. 结论: bcl-2基因异常表达可能与神经母细胞或原始神经嵴细胞逃脱凋亡, 不能正常成熟或消退, 而发展成NB及NB的进展有关. AI高预后好. BEI和AI的检测可为了解NB的发病机制和判断预后提供实验依据及手段." @default.
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- W3032399560 date "1998-01-15" @default.
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- W3032399560 title "The Role of bcl-2 Gene Regulating Function and Apoptosis in Oncogenesis of Neuroblastoma" @default.
- W3032399560 doi "https://doi.org/10.3760/cma.j.issn.0253-3006.1998.01.011" @default.
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