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- W3032408504 abstract "ObjectiveTo study the effect of neuroepithelial cell transforming gene 1(Net1) on the cellular radiosensitivity and underlying mechanism.MethodsReal-time quantitative PCR was used to measure the variations in Net1 expression level upon irradiation. Radiosensitivity was analyzed by colony-forming assay after Net1-siRNAs. Net1-associated proteins were identified by co-immunoprecipitation.ResultsThe Net1 mRNA level in the cells was increased significantly (t =-10.52, P<0.05) after irradiation. Compared to the control group, siRNA-mediated silencing of Net1 enhanced cell radiosensitivity (t=15.31, 11.65, P<0.05). Net1 was found to interact with Ku70, Ku80 and DNA-PKcs under either normal conditions or after irradiation.ConclusionsNet1 could protect cells from irradiation by interaction with DNA repair proteins in non-homologous end joining pathway.Key words: Net1; Radiosensitivity; DNA double-strand break; Non-homologous end joining" @default.
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- W3032408504 date "2015-01-25" @default.
- W3032408504 modified "2023-09-29" @default.
- W3032408504 title "Effect and mechanism of neuroepithelial cell transforming gene 1 on cellular radiosensitivity" @default.
- W3032408504 doi "https://doi.org/10.3760/cma.j.issn.0254-5098.2015.01.009" @default.
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