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• W3032413159 abstract "ObjectiveTo explore the effect and mechanism of resveratrol (RES) on the formation of glioblastoma cells in nude mice.MethodsTen 4-week-old female BALB/c nude mice were randomly divided into resveratrol group and dimethyl sulfoxide saline control group according to the number, with 5 mice in each group. Human malignant glioma U251 cell suspension was subcutaneously inoculated into the right forearm of nude mice by subcutaneous transplantation to establish a malignant glioma model in nude mice. On the 10th day after tumor implantation, tumor was obviously touched subcutaneously in the right forelimb of nude mice, indicating successful modeling. The mice in the resveratrol group were given 200 μL resveratrol solution at a concentration of 50 mmol/L. The nude mice in the control group were given the same concentration of dimethyl sulfoxide saline. Give the medicine once every three days for a total of 7 times. The longest diameter and the shortest diameter of the tumors were recorded before the first dose and the volume of the tumors was calculated. The tumor size was measured 3 days after each dose. The animals were killed after a final measurement of tumor size. Western blot was used to detect the expression of FOXP2 protein in resveratrol group and control group, and real-time fluorescence quantitative PCR (qPCR) was used to detect the expression of microRNA-9.ResultsTen nude mice in resveratrol group and control group were successfully established as transplanted malignant glioma models. The volume of tumors in the resveratrol group was (12.94±10.17)mm3 on the 10th day after subcutaneous implantation of tumors, and that in the control group was (6.46±2.67)mm3. After the first, second, third and fourth administration, The volume of tumors in resveratrol group was (25.58±16.41)mm3, (32.33±17.62)mm3, (58.81±7.66) mm3, (97.67±20.76) mm3, respectively. The volume of tumors in control group was(12.02±8.71)mm3, (30.73±15.74)mm3, (52.88±20.03)mm3, (88.50±37.01)mm3, respectively. The volume of tumors in resveratrol group was larger than that in control group, but the difference was not significant (all P values>0.05). After the 5th, 6th and 7th administration, the volume of tumors in resveratrol group was (114.94 ± 29.35) mm3, (237.42±23.3) mm3 and(231.27±12.6)mm3, respectively, which were smaller than those in control group (191.71±53.79) mm3, (314.67±24.4) mm3 and(374.03±21.6)mm3, with significant difference between the two groups (t=-2.802, -5.114, -6.320, all P values<0.05). The relative expression of FOXP2 protein in resveratrol group (165.51±16.31) was lower than that in control group (100.60±41.75) and the difference was significant (t=3.238, P<0.05). The relative expression of microRNA-9 in resveratrol group (0.971±0.369) was higher than that in control group (0.496±0.008). The difference between the two groups was significant (t=2.878, P<0.05).ConclusionsResveratrol can inhibit the formation of glioblastoma cells in nude mice. The mechanism may be achieved by adjusting the miR-9-FOXP2 signal.Key words: Glioma; Mice, nude; Resveratrol; Fork frame protein P2; Micro RNA; Models, animal" @default.
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• W3032413159 date "2019-02-06" @default.
• W3032413159 modified "2023-09-26" @default.
• W3032413159 title "Effect of resveratrol on the growth of malignant glioma in nude mice and its mechanism" @default.
• W3032413159 doi "https://doi.org/10.3760/cma.j.issn.2095-7041.2019.01.013" @default.
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