Matches in SemOpenAlex for { <https://semopenalex.org/work/W3032444453> ?p ?o ?g. }
- W3032444453 endingPage "1160" @default.
- W3032444453 startingPage "1152" @default.
- W3032444453 abstract "Abstract The paper describes the preparation of polymeric hydrogels, loaded with bupivacaine, which could represent a good alternative in clinical dentistry as local anesthetics. The hydrogels were prepared by condensation using an amidation reaction between a natural polymer (chitosan) and a synthetic one, poly[(maleic anhydride)‐ alt ‐(vinyl acetate)]. Infrared spectroscopy studies confirmed crosslinking through the presence of amide bonds, formed between the two types of polymer chains. Scanning electron microscopy results demonstrated that the hydrogels have a porous structure, the pore dimensions being non‐uniform with diameters between 200 and 600 μm. Hydrogels presented good bupivacaine inclusion and release capacity whereas theoretical analysis confirmed the validity of the generalized fractal model, reinforcing a csavi‐universal pattern of drug release. Cytotoxicity tests on human dermal fibroblasts revealed that the obtained hydrogels are not cytotoxic. In vivo , the bupivacaine‐loaded hydrogels presented anesthetic effects after 15 min and no side effects were observed. This system has the advantage of alleviating or eliminating pain associated with invasive procedures and avoiding direct contact of the drug with tissues, leading thus to the prevention of side effects. © 2020 Society of Chemical Industry" @default.
- W3032444453 created "2020-06-05" @default.
- W3032444453 creator A5006619313 @default.
- W3032444453 creator A5016317872 @default.
- W3032444453 creator A5023156014 @default.
- W3032444453 creator A5031101512 @default.
- W3032444453 creator A5050517302 @default.
- W3032444453 creator A5056130109 @default.
- W3032444453 creator A5060313454 @default.
- W3032444453 creator A5065033988 @default.
- W3032444453 creator A5079220926 @default.
- W3032444453 date "2020-07-11" @default.
- W3032444453 modified "2023-10-18" @default.
- W3032444453 title "Bupivacaine‐loaded chitosan hydrogels for topical anesthesia in dentistry" @default.
- W3032444453 cites W1830623697 @default.
- W3032444453 cites W1928534968 @default.
- W3032444453 cites W1967180835 @default.
- W3032444453 cites W1984335257 @default.
- W3032444453 cites W1984805412 @default.
- W3032444453 cites W1987271774 @default.
- W3032444453 cites W2052973806 @default.
- W3032444453 cites W2059741600 @default.
- W3032444453 cites W2079881591 @default.
- W3032444453 cites W2097275321 @default.
- W3032444453 cites W2103137547 @default.
- W3032444453 cites W2125585265 @default.
- W3032444453 cites W2135360410 @default.
- W3032444453 cites W2144081123 @default.
- W3032444453 cites W2158219146 @default.
- W3032444453 cites W2162602938 @default.
- W3032444453 cites W2330757772 @default.
- W3032444453 cites W2465793952 @default.
- W3032444453 cites W2581108109 @default.
- W3032444453 cites W2908205586 @default.
- W3032444453 cites W2908854052 @default.
- W3032444453 cites W2919059684 @default.
- W3032444453 cites W2944395239 @default.
- W3032444453 cites W2947825446 @default.
- W3032444453 cites W2948020554 @default.
- W3032444453 cites W2968255272 @default.
- W3032444453 cites W2973360919 @default.
- W3032444453 doi "https://doi.org/10.1002/pi.6052" @default.
- W3032444453 hasPublicationYear "2020" @default.
- W3032444453 type Work @default.
- W3032444453 sameAs 3032444453 @default.
- W3032444453 citedByCount "13" @default.
- W3032444453 countsByYear W30324444532021 @default.
- W3032444453 countsByYear W30324444532022 @default.
- W3032444453 countsByYear W30324444532023 @default.
- W3032444453 crossrefType "journal-article" @default.
- W3032444453 hasAuthorship W3032444453A5006619313 @default.
- W3032444453 hasAuthorship W3032444453A5016317872 @default.
- W3032444453 hasAuthorship W3032444453A5023156014 @default.
- W3032444453 hasAuthorship W3032444453A5031101512 @default.
- W3032444453 hasAuthorship W3032444453A5050517302 @default.
- W3032444453 hasAuthorship W3032444453A5056130109 @default.
- W3032444453 hasAuthorship W3032444453A5060313454 @default.
- W3032444453 hasAuthorship W3032444453A5065033988 @default.
- W3032444453 hasAuthorship W3032444453A5079220926 @default.
- W3032444453 hasConcept C108586683 @default.
- W3032444453 hasConcept C127413603 @default.
- W3032444453 hasConcept C136229726 @default.
- W3032444453 hasConcept C159985019 @default.
- W3032444453 hasConcept C163588942 @default.
- W3032444453 hasConcept C171250308 @default.
- W3032444453 hasConcept C178790620 @default.
- W3032444453 hasConcept C185592680 @default.
- W3032444453 hasConcept C188027245 @default.
- W3032444453 hasConcept C192562407 @default.
- W3032444453 hasConcept C2779732960 @default.
- W3032444453 hasConcept C2779820397 @default.
- W3032444453 hasConcept C2781328992 @default.
- W3032444453 hasConcept C42360764 @default.
- W3032444453 hasConcept C521977710 @default.
- W3032444453 hasConcept C71924100 @default.
- W3032444453 hasConcept C98274493 @default.
- W3032444453 hasConceptScore W3032444453C108586683 @default.
- W3032444453 hasConceptScore W3032444453C127413603 @default.
- W3032444453 hasConceptScore W3032444453C136229726 @default.
- W3032444453 hasConceptScore W3032444453C159985019 @default.
- W3032444453 hasConceptScore W3032444453C163588942 @default.
- W3032444453 hasConceptScore W3032444453C171250308 @default.
- W3032444453 hasConceptScore W3032444453C178790620 @default.
- W3032444453 hasConceptScore W3032444453C185592680 @default.
- W3032444453 hasConceptScore W3032444453C188027245 @default.
- W3032444453 hasConceptScore W3032444453C192562407 @default.
- W3032444453 hasConceptScore W3032444453C2779732960 @default.
- W3032444453 hasConceptScore W3032444453C2779820397 @default.
- W3032444453 hasConceptScore W3032444453C2781328992 @default.
- W3032444453 hasConceptScore W3032444453C42360764 @default.
- W3032444453 hasConceptScore W3032444453C521977710 @default.
- W3032444453 hasConceptScore W3032444453C71924100 @default.
- W3032444453 hasConceptScore W3032444453C98274493 @default.
- W3032444453 hasFunder F4320323308 @default.
- W3032444453 hasIssue "11" @default.
- W3032444453 hasLocation W30324444531 @default.
- W3032444453 hasOpenAccess W3032444453 @default.
- W3032444453 hasPrimaryLocation W30324444531 @default.