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- W3032448624 abstract "ObjectiveTo investigate the association between kidney function and cerebrovascular disease,and find out the prevalence of chronic kidney disease (CKD) in Chinese cerebral infarction patients.MethodsClinical data of 419 patients who underwent intra- and extracranial vessel examination in our department from January 2008 to February 2013 were retrospectively reviewed and analyzed.We evaluated the degree and extent of cerebrovascular stenosis by carotid duplex ultrasound, transcranial Doppler ultrasound,magnetic resonance angiography,computed tomography angiography and digital subtraction angiography,evaluated white matter lesions (WML) by MRI,and measured the kidney function by the adaption of MDRD (Modification of Diet in Renal Disease) equation.Then we analyzed the association between them in these patients.Results(1) In 419 patients,the prevalence of CKD was 12.4% (52).The patients included 222 patients without cerebrovascular stenosis,63 patients with mild stenosis,63 patients with moderate stenosis, 44 patients with severe stenosis and 27 patients with occlusion.CKD （Z=－3.070，P=0.002） and renal function （r=0.194，P<0.01）were associated with cerebrovascular stenosis.(2) In 419 patients,103 patients had intracranial vascular stenosis,45 patients had extracranial vascular stenosis,and 49 patients had intra- and extracranial vascular stenosis.Compared with the patients without stenosis,CKD was associated with intracranial stenosis（χ2=4.784，P=0.032）,extracranial stenosis（χ2=8.732，P=0.003）,and intra- and extracranial stenosis（χ2=5.308，P=0.021）.(3) In 175 patients,including 82 patients with mild WML, 63 patients with moderate WML, and 30 patients with severe WML, the CKD stage was significantly associated with the degree of WML.(4) In the Logistic regression analysis, CKD was an independent risk factor of cerebrovascular stenosis (OR=0.485,95%CI 0.254—0.927, P=0.029),and CKD (OR=0.395,95%CI 0.159—0.978）was an independent risk factor of extracranial vascular stenosis,but not an independent risk factor of WML.ConclusionsCKD patients suffer more severe cerebrovascular stenosis,and have higher prevalence of extracranial vascular stenosis.The prevalence of CKD in cerebral infraction patients is higher than that in the national epidemiological investigation.Key words: Brain infarction; Cerebrovascular disorders; Leukoencephalopathies; Constriction,pathologic; Renal insufficiency,chronic" @default.
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- W3032448624 date "2014-11-08" @default.
- W3032448624 modified "2023-09-23" @default.
- W3032448624 title "Association between cerebrovascular disease and chronic kidney disease in Chinese cerebral infarction patients" @default.
- W3032448624 doi "https://doi.org/10.3760/cma.j.issn.1006-7876.2014.11.003" @default.
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