FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3032453453> ?p ?o ?g. }

• W3032453453 endingPage "317" @default.
• W3032453453 startingPage "313" @default.
• W3032453453 abstract "ObjectiveTo explore curative effect, effective dose and its possible mechanisms of dopamine D3 receptor (DAD3R) agonist BP897 in treatment of mice with tourette syndrome(TS).MethodsAccording to random number table, random number table method, a total of 60 healthy male ICR mice were average divided into 6 groups(n=10 for each group): model group, BP897Ⅰ, Ⅱ, Ⅲ group, positive control group and normal control group.Except normal control group, the other 5 groups were established mice model of TS.Intragastric administration to mice every day from 8th day of experiment: normal control group and model group with 0.1 mL normal saline ; positive control group with haloperidol 0.5 mg/kg; BP897Ⅰ, Ⅱ, Ⅲ group with BP897 0.3, 1.0, 3.0 mg/kg. Upon successful established TS mice model immediately, 7th and 28th of intragastric administration, stereotyped behavior scores of mice were got in double-blind way.On the 28th day of intragastric administration, DAD3R, dopamine transporter(DAT) and dopamine contents in mice brain tissues were detected by enzyme-linked immunosorbent assay(ELISA), and use statistical methods to compare differences of stereotyped behavior scores, DAD3R, DAT and dopamine contents among different groups, and analyze relationship between DAD3R and dopamine, DAT and dopamine.There were no significant differences among 6 groups in general conditions, such as body weight(P>0.05).Results①Comparison of stereotyped behavior scores of mice on 7th day and 28th day of intragastric administration: BP897Ⅱ and Ⅲ group were significantly lower than those in model group, respectively, BP897Ⅱ group were significantly lower than those in BP897Ⅰ group, and BP897Ⅲ group were significantly lower than those in BP897Ⅱ group, too, and the differences were significant(P 0.05). ②Comparison of DAD3R, DAT and dopamine contents in mice brain tissues on 28th day of intragastric administration: Model group were significantly lower than those in BP897Ⅲ group, positive control group and normal control group, respectively, and in BP897Ⅲ group were significantly lower than those in positive control group, too, and the differences were significant(P 0.05). ③DAD3R and DAT contents in mice brain tissues were both positively correlated with dopamine content(r=0.765, 0.766; P<0.001).Conclusions1.0-3.0 mg/kg dose of BP897 can treat mice with TS effectively, and 3.0 mg/kg dose of BP897 can much better control the stereotyped behavior of mice with TS, which can reach the same curative effect with haloperidol.Key words: BP897; Tourette syndrome; Receptors, dopamine D3; Dopamine plasma membrane transport proteins; Dopamine; Mice, inbred ICR" @default.
• W3032453453 created "2020-06-05" @default.
• W3032453453 creator A5014011210 @default.
• W3032453453 creator A5068289835 @default.
• W3032453453 date "2015-06-01" @default.
• W3032453453 modified "2023-09-23" @default.
• W3032453453 title "Study on curative effect and possible mechanisms of dopamine D3 receptor agonist BP897 in treatment of mice with tourette syndrome" @default.
• W3032453453 doi "https://doi.org/10.3877/cma.j.issn.1673-5250.2015.03.006" @default.
• W3032453453 hasPublicationYear "2015" @default.
• W3032453453 type Work @default.
• W3032453453 sameAs 3032453453 @default.
• W3032453453 citedByCount "0" @default.
• W3032453453 crossrefType "journal-article" @default.
• W3032453453 hasAuthorship W3032453453A5014011210 @default.
• W3032453453 hasAuthorship W3032453453A5068289835 @default.
• W3032453453 hasConcept C118552586 @default.
• W3032453453 hasConcept C120069818 @default.
• W3032453453 hasConcept C126322002 @default.
• W3032453453 hasConcept C134018914 @default.
• W3032453453 hasConcept C137183658 @default.
• W3032453453 hasConcept C170493617 @default.
• W3032453453 hasConcept C199596767 @default.
• W3032453453 hasConcept C2776755682 @default.
• W3032453453 hasConcept C2777026814 @default.
• W3032453453 hasConcept C2777397205 @default.
• W3032453453 hasConcept C2778258207 @default.
• W3032453453 hasConcept C2778938600 @default.
• W3032453453 hasConcept C2780948584 @default.
• W3032453453 hasConcept C513476851 @default.
• W3032453453 hasConcept C71924100 @default.
• W3032453453 hasConceptScore W3032453453C118552586 @default.
• W3032453453 hasConceptScore W3032453453C120069818 @default.
• W3032453453 hasConceptScore W3032453453C126322002 @default.
• W3032453453 hasConceptScore W3032453453C134018914 @default.
• W3032453453 hasConceptScore W3032453453C137183658 @default.
• W3032453453 hasConceptScore W3032453453C170493617 @default.
• W3032453453 hasConceptScore W3032453453C199596767 @default.
• W3032453453 hasConceptScore W3032453453C2776755682 @default.
• W3032453453 hasConceptScore W3032453453C2777026814 @default.
• W3032453453 hasConceptScore W3032453453C2777397205 @default.
• W3032453453 hasConceptScore W3032453453C2778258207 @default.
• W3032453453 hasConceptScore W3032453453C2778938600 @default.
• W3032453453 hasConceptScore W3032453453C2780948584 @default.
• W3032453453 hasConceptScore W3032453453C513476851 @default.
• W3032453453 hasConceptScore W3032453453C71924100 @default.
• W3032453453 hasIssue "03" @default.
• W3032453453 hasLocation W30324534531 @default.
• W3032453453 hasOpenAccess W3032453453 @default.
• W3032453453 hasPrimaryLocation W30324534531 @default.
• W3032453453 hasRelatedWork W2245991205 @default.
• W3032453453 hasRelatedWork W2353389491 @default.
• W3032453453 hasRelatedWork W2361654929 @default.
• W3032453453 hasRelatedWork W2366849244 @default.
• W3032453453 hasRelatedWork W2373747957 @default.
• W3032453453 hasRelatedWork W2374869958 @default.
• W3032453453 hasRelatedWork W2380050493 @default.
• W3032453453 hasRelatedWork W2380426620 @default.
• W3032453453 hasRelatedWork W2383323390 @default.
• W3032453453 hasRelatedWork W2385751782 @default.
• W3032453453 hasRelatedWork W2391631918 @default.
• W3032453453 hasRelatedWork W2392043223 @default.
• W3032453453 hasRelatedWork W2414021279 @default.
• W3032453453 hasRelatedWork W2416152014 @default.
• W3032453453 hasRelatedWork W2418130161 @default.
• W3032453453 hasRelatedWork W2462784221 @default.
• W3032453453 hasRelatedWork W3029501207 @default.
• W3032453453 hasRelatedWork W3031380121 @default.
• W3032453453 hasRelatedWork W3032556078 @default.
• W3032453453 hasRelatedWork W3032672453 @default.
• W3032453453 hasVolume "11" @default.
• W3032453453 isParatext "false" @default.
• W3032453453 isRetracted "false" @default.
• W3032453453 magId "3032453453" @default.
• W3032453453 workType "article" @default.