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- W3032458667 endingPage "293" @default.
- W3032458667 startingPage "293" @default.
- W3032458667 abstract "Fucosylated chondroitin sulfate (fCS) is a glycosaminoglycan (GAG) polysaccharide with a unique structure, displaying a backbone composed of alternating N-acetyl-d-galactosamine (GalNAc) and d-glucuronic acid (GlcA) units on which l-fucose (Fuc) branches are installed. fCS shows several potential biomedical applications, with the anticoagulant activity standing as the most promising and widely investigated one. Natural fCS polysaccharides extracted from marine organisms (Echinoidea, Holothuroidea) present some advantages over a largely employed antithrombotic drug such as heparin, but some adverse effects as well as a frequently found structural heterogeneity hamper its development as a new drug. To circumvent these drawbacks, several efforts have been made in the last decade to obtain synthetic and semi-synthetic fCS oligosaccharides and low molecular weight polysaccharides. In this Review we have for the first time collected these reports together, dividing them in two topics: (i) total syntheses of fCS oligosaccharides and (ii) semi-synthetic approaches to fCS oligosaccharides and low molecular weight polysaccharides as well as glycoclusters displaying multiple copies of fCS species." @default.
- W3032458667 created "2020-06-05" @default.
- W3032458667 creator A5004198503 @default.
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- W3032458667 creator A5017156780 @default.
- W3032458667 creator A5018269051 @default.
- W3032458667 creator A5049172291 @default.
- W3032458667 date "2020-06-01" @default.
- W3032458667 modified "2023-10-02" @default.
- W3032458667 title "(Semi)-Synthetic Fucosylated Chondroitin Sulfate Oligo- and Polysaccharides" @default.
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- W3032458667 doi "https://doi.org/10.3390/md18060293" @default.
- W3032458667 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7345195" @default.
- W3032458667 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32492857" @default.
- W3032458667 hasPublicationYear "2020" @default.
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