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- W3032464629 abstract "Melanoma is the most serious type of skin cancer and hard to be cured by traditional therapy when metastasis occurs in the patients. Since the immunogenicity of the melanoma was discovered,the biological and immune therapy for this tumour became a hot spot of research. The clinical research on adoptive cell transfer has developed rapidly in recent years and the most remarkable effecs obtained were the infusing of autotumor infiltrating lymphocyte with over a 70% partial response. In the mean time,the research on monoclonal antibodies and signalling pathway inhibitor has been progressing quickly. These researchs have provided new approaches to the biological and immune therapy. The effects of various medicine with different mechanisms will be demonstrated in the near future,especially ipilimumab,the anti-CTLA-4 monoclonal antibody and PLX4032,an highly selective inhibitor of BRAF.Key words: Malignant melanoma; Tumor infiltrating lymphocytes; Anti-CTLA-4 monoclonal antibody; Inhibition of BRAF" @default.
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- W3032464629 date "2011-05-05" @default.
- W3032464629 modified "2023-09-24" @default.
- W3032464629 title "Progress Study on the biological and immune therapy for malignant melanoma" @default.
- W3032464629 doi "https://doi.org/10.3760/cma.j.issn.1673-4394.2011.03.011" @default.
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