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- W3032468122 abstract "目的 探讨早期应用大剂量阿托伐他汀强化治疗对老年急性冠状动脉综合征(ACS)患者冠状动脉炎症的影响,以及不同剂量的作用是否存在差异.方法 192例ACS老年患者随机分为常规剂量阿托伐他汀组和大剂量阿托伐他汀组,均给予常规治疗标准.常规剂量组95例加用阿托伐他汀10 mg/d,大剂量组97例加用阿托伐他汀40 mg/d.在患者入院后和治疗第5天、1个月后测定超敏C-反应蛋白(hs-CRP)和血脂水平.结果 大剂量组在治疗第5天和1个月后超敏C-反应蛋白(hs-CRP)水平明显低于基础水平(P＜0.01或＜0.001),而常规剂量组仅在1个月后hs-CRP水平明显低于基础水平(P＜0.01),与常规剂量组比较,大剂量组治疗第5天和1个月后的hs-CRP水平降低更显著(P均＜0.05),1个月内的心律失常、再发心肌缺血及心力衰竭发生率明显降低(P均＜0.05).结论 在ACS早期应用大剂量阿托伐他汀强化治疗能迅速明显降低hs-CRP水平,且这是一种独立于调脂作用之外的抗炎效应,对减少心血管事件发生率有一定的辅助作用。" @default.
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- W3032468122 date "2007-03-01" @default.
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- W3032468122 title "Anti-inflammatory effect of high-dose atrovastatin in senile acute coronary syndrome" @default.
- W3032468122 doi "https://doi.org/10.3760/cma.j.issn.1008-6315.2007.03.005" @default.
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