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- W3032468528 abstract "ObjectiveTo analyze the causes，neuroimaging and clinical manifestations of isolated unilateral pontine infarction and to discuss its relationship to progressive motor deficit (PMD).MethodsAll 58 patients with isolated acute unilateral pontine infarction confirmed by magnetic resonance imaging (MRI) were recruited in this study for retrospective review.Thirty-one patients of them had brain and neck multi-slice spiral CT angiography (CTA) within 1 week after admission.PMD severity was accessed using the dynamic National Institutes of Health Stroke Scale (NIHSS) within 5 days after onset.All 58 patients were divided into two groups: patients with PMD (23 cases) in group 1 and patients without PMD (35 cases) in group 2.Two groups were compared for the risk factors，initial NIHSS scores，modified Rankin Scale (mRS) scores at 1 month after onset，clinical manifestations，infarction distribution，size and morphology of infarctions and basilar artery lesions.ResultsThe major cause was pathologic changes in basilar artery branch in both groups (6/12 in group 1 and 10/19 in group 2).The proportion of patients with infarction extending to the pontine surface in group 1 was higher than that in group 2 (21/23，91.3% vs 20/35，57.1%，χ2=7.817，P=0.005).Initial NIHSS score in group 1 was higher than that in group 2 (6.7±2.9 vs 4.5±2.4，t=3.121，P=0.003).mRS score at 1 month after onset in group 1 was higher than that in group 2 (2.2±1.1 vs 1.5±0.8，t=2.909，P=0.004).The Logistic regression analysis showed that isolated unilateral pontine infarction extending to the pontine surface was positively related to PMD (odds ratio 9.670，95% confidence interval 1.171-79.856，P=0.035).ConclusionsProgressive isolated unilateral pontine infarction is mostly caused by pathologic changes in basilar artery branch.Patients with PMD have a more severe initial clinical manifest and they have a worse short-term prognosis than patients without PMD.Isolated unilateral pontine infarction extending to the pontine surface may be a risk predictor in stroke evolution.Key words: Brain infarction; Pons; Movement disorders; Vertebrobasilar insufficiency; Magnetic resonance imaging" @default.
- W3032468528 created "2020-06-05" @default.
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- W3032468528 date "2013-03-08" @default.
- W3032468528 modified "2023-09-24" @default.
- W3032468528 title "Progressive motor deficit caused by isolated unilateral pontine infarction extending to the pontine surface" @default.
- W3032468528 doi "https://doi.org/10.3760/cma.j.issn.1006-7876.2013.03.008" @default.
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