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- W3032483301 abstract "Abstract White adipose tissue inflammation, in part via myeloid cell contribution, is central to obesity pathogenesis. Mechanisms regulating adipocyte inflammatory potential and consequent impact of such inflammation in disease pathogenesis remain poorly defined. We show that activation of the type I interferon (IFN)/IFNα receptor (IFNAR) axis amplifies adipocyte inflammatory vigor and uncovers dormant gene expression patterns resembling inflammatory myeloid cells. IFNβ-sensing promotes adipocyte glycolysis, while glycolysis inhibition impeded IFNβ-driven intra-adipocyte inflammation. Obesity-driven induction of the type I IFN axis and activation of adipocyte IFNAR signaling contributes to obesity-associated pathogenesis in mice. Notably, IFNβ effects are conserved in human adipocytes and detection of the type I IFN/IFNAR axis-associated signatures positively correlates with obesity-driven metabolic derangements in humans. Collectively, our findings reveal a capacity for the type I IFN/IFNAR axis to regulate unifying inflammatory features in both myeloid cells and adipocytes and hint at an underappreciated contribution of adipocyte inflammation in disease pathogenesis." @default.
- W3032483301 created "2020-06-05" @default.
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- W3032483301 date "2020-06-02" @default.
- W3032483301 modified "2023-10-15" @default.
- W3032483301 title "Type I interferon sensing unlocks dormant adipocyte inflammatory potential" @default.
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- W3032483301 cites W2038139581 @default.
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- W3032483301 doi "https://doi.org/10.1038/s41467-020-16571-4" @default.
- W3032483301 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7265526" @default.
- W3032483301 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32488081" @default.
- W3032483301 hasPublicationYear "2020" @default.
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