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- W3032488476 abstract "ObjectiveTo investigate the B-cell epitope in the UL148 gene of human cytomegalovirus (HCMV).MethodsThe secondary structure were analyzed by the improved self-optimized prediction method (SOPMA), Garnier-Osguthorpe-Robson(GOR), Hierarchical neutral network (HNN) Programs based on the amino acid sequence of HCMVUL148 gene. In combination with transmembrane, hydrophilicity, accessibility, flexibility and antigenicity analysis to selected the potential candidates of linear B-cell epitopes.ResultsHCMV pUL148 contains 316 amino acid residues, the relative molecular mass was 36 kD and the isoelectric point was 9.15; Variety of forecasting methods were prompted that the 14-21, 98-106, 132-139, 174-181, 191-197, 267-272, 235-240 amino acid sequence regions were main random coil or β-turn model in the secondary structure; The 1-285 amino acids was a transmembrane region and the extracellular regions was 1-285 amino acids, all of that were predicted by the TMHMM.ConclusionsComprehensive analysis that the 265-275, 221-229, 18-25 amino acid sequence regions were main random coil or β-turn model in the secondary structure, and consider of the average antigenicity index (AI) of epitope peptide investigation, three peptides were selected as potential candidates of linear B-cell epitopes.Key words: human cytomegalovirus; UL148; B-cell epitope; multi-peptide immunization" @default.
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- W3032488476 date "2013-08-01" @default.
- W3032488476 modified "2023-09-25" @default.
- W3032488476 title "Prediction and Analysis of B-Cell Epitope in the UL148 Gene of Human Cytomegalovirus" @default.
- W3032488476 doi "https://doi.org/10.3877/cma.j.issn.1673-5250.2013.04.004" @default.
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