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- W3032493972 abstract "ObjectiveTo investigate the value of serum miRNA-15b and miRNA-34a as novel Biomarkers for the post-chemotherapy evaluation of ⅢB and Ⅳ non-small cell lung cancer.MethodsThe serum of 201 ⅢB and Ⅳ non-small cell lung cancer patients taking chemotherapy at our hospital from January 1st, 2010 to January 1st, 2016 were collected before and after chemotherapy. The serum of 20 healthy objects were collected as controls. Total RNA was extracted from the serum, RT-PCR method was used to detect the levels of miRNA-15b and miRNA34a in serum. The CT value of each sample was recorded. The correlation between the CT value and each patient’s treatment effect was analyzed.Results① After 2 treatment courses, 69 got PR, 94 SD, and 38 PD. ② The CT values of miRNA-15b and miRNA-34a were (35.50±2.51) and (36.00±2.00) in the healthy control group, respectively. The CT value of miRNA-15b was (28.43±4.81 ) before and was (31.85±7.00) after chemotherapy in the observation group. The CT value of miRNA-34a was (30.43±5.12) before and was (32.00±6.28) after chemotherapy in the observation group., The CT values of miRNA-15b and miRNA-34a were significantly higher in the observation group than in the healthy control group before and after chemotherapy, with statistical differences (P<0.05). ③Compared with those before chemotherapy, the CT values of miRNA-15b and miRNA-34a in the PR group and PD group significantly changed after chemotherapy, with statistical differences (P<0.05).ConclusionThe detection of serum miRNA-15b and miRNA-34a has important clinical value for the post-chemotherapy evaluation of ⅢB and Ⅳ non-small cell lung cancer.Key words: MiRNA-15b; MiRNA-34a; Non-small Cell Lung Cancer; Chemotherapy; Assessment" @default.
- W3032493972 created "2020-06-05" @default.
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- W3032493972 date "2017-01-01" @default.
- W3032493972 modified "2023-09-24" @default.
- W3032493972 title "Serum miRNA-15b and miRNA-34a as novel biomarkers for post-chemotherapy evaluation of IIIB and IV non-small cell lung cancer" @default.
- W3032493972 doi "https://doi.org/10.3760/cma.j.issn.1007-1245.2017.01.011" @default.
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