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- W3032495608 abstract "ObjectiveTo explore the clinical differences between patients with early-onset myasthenia gravis(EOMG)and those with late-onset myasthenia gravis(LOMG). MethodsThis was a retrospective study enrolling 157 MG patients.Based on the age of onset, patients were divided into the EOMG group(n=85)and the LOMG group(n=72). The groups were compared on clinical characteristics, including clinical manifestations, MG classification, electrophysiological findings on repetitive nerve stimulation(RNS), single fiber electromyography(SFEMG), levels of antibody against acetylcholine receptors(Ach-R Ab), antibody to muscle-specific kinase(MuSK Ab), titin antibody(Titin Ab), ryanodine receptor antibody(RyR Ab), thyroid function, thymectomy, thymus pathology and responses to treatment. ResultsThe mean ages of onset were markedly different〔(40.9±9.7)years vs.(62.0±12.2)years, P 0.05). Moreover, patients in the EOMG group were more likely to have abnormal thyroid function and higher percentages of receiving steroids, tacrolimus, plasma exchange therapy, and thymectomy(P<0.05). ConclusionsThe clinical profiles of LOMG are different from those of EOMG in clinical manifestations, thyroid function, thymectomy frequency, striational antibody levels and disease-modifying drug options.Key words: Myasthenia gravis; Recepors, cholinergic" @default.
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- W3032495608 date "2018-05-14" @default.
- W3032495608 modified "2023-09-23" @default.
- W3032495608 title "Clinical differences between early-and late-onset myasthenia" @default.
- W3032495608 doi "https://doi.org/10.3760/cma.j.issn.0254-9026.2018.05.006" @default.
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