FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3032497735> ?p ?o ?g. }

• W3032497735 endingPage "e2981" @default.
• W3032497735 startingPage "e2970" @default.
• W3032497735 abstract "Abstract Context The contribution of blood extracellular vesicular (EV) programmed death-ligand 1 (PD-L1) and programmed death-1 (PD-1) in papillary thyroid cancer (PTC) is uncertain. Objective We sought to determine the relationship of EV PD-L1/PD-1 with the clinical features of pediatric PTC and the role of EV PD-L1 in immunosuppression. Main Outcome Measures Plasma levels of EV and soluble PD-L1 and PD-1 and levels of plasma cytokines in children with PTC and controls were determined by enzyme-linked immunosorbent assay. Levels of tumor PD-L1 and the tumor-infiltrating lymphocyte (TIL) score were determined by immunohistochemistry. Correlations of the plasma PD-L1/PD-1 level with clinicopathological characteristics, levels of plasma cytokines, tumor PD-L1 expression, and TIL score were analyzed. T-cell suppression by EVs from PTC patients was determined by incubation of PD-L1high or PD-L1low EVs with activated CD8+ T cells. Changes in CD69 and PD-1 expression and changes in tumor necrosis factor-α (TNFα) and interferon-γ (IFNγ) secretion were measured by flow cytometry. Results The levels of plasma PD-L1/PD-1 were significantly higher in children with PTC than in controls. The levels of plasma EV PD-L1 significantly correlated with tumor T stage, tumor PD-L1 expression, TIL score, and plasma cytokine content. Levels of plasma soluble PD-1 significantly correlated with patient age, plasma EV PD-L1, and IFNα concentration. PD-L1high EVs significantly inhibited the activation of CD8+ T cells. Conclusions Plasma levels of EV PD-L1, but not soluble PD-L1, were associated with tumor T stage in children with PTC. Plasma EV PD-L1 emerges as a useful metric for assessing tumor T stage and T cell suppression in PTC." @default.
• W3032497735 created "2020-06-05" @default.
• W3032497735 creator A5001732123 @default.
• W3032497735 creator A5010806417 @default.
• W3032497735 creator A5012545118 @default.
• W3032497735 creator A5029816917 @default.
• W3032497735 creator A5033383665 @default.
• W3032497735 creator A5033986181 @default.
• W3032497735 creator A5047900312 @default.
• W3032497735 creator A5055388661 @default.
• W3032497735 creator A5066521865 @default.
• W3032497735 creator A5073501391 @default.
• W3032497735 creator A5081360289 @default.
• W3032497735 creator A5085653336 @default.
• W3032497735 date "2020-05-27" @default.
• W3032497735 modified "2023-10-14" @default.
• W3032497735 title "EV PD-L1 is Correlated With Clinical Features and Contributes to T Cell Suppression in Pediatric Thyroid Cancer" @default.
• W3032497735 cites W1913780655 @default.
• W3032497735 cites W1967792499 @default.
• W3032497735 cites W2010121426 @default.
• W3032497735 cites W2040793402 @default.
• W3032497735 cites W2048657818 @default.
• W3032497735 cites W2086437355 @default.
• W3032497735 cites W2103383530 @default.
• W3032497735 cites W2107556275 @default.
• W3032497735 cites W2133294507 @default.
• W3032497735 cites W2143772132 @default.
• W3032497735 cites W2171651941 @default.
• W3032497735 cites W2183602213 @default.
• W3032497735 cites W2190935753 @default.
• W3032497735 cites W2274758479 @default.
• W3032497735 cites W2292821496 @default.
• W3032497735 cites W2324094374 @default.
• W3032497735 cites W2332521027 @default.
• W3032497735 cites W2334212908 @default.
• W3032497735 cites W2338494814 @default.
• W3032497735 cites W2339208679 @default.
• W3032497735 cites W2340636398 @default.
• W3032497735 cites W2403322023 @default.
• W3032497735 cites W2498914772 @default.
• W3032497735 cites W2509486054 @default.
• W3032497735 cites W2555055728 @default.
• W3032497735 cites W2567639438 @default.
• W3032497735 cites W2592133876 @default.
• W3032497735 cites W2600057763 @default.
• W3032497735 cites W2605377619 @default.
• W3032497735 cites W2615907969 @default.
• W3032497735 cites W2741886782 @default.
• W3032497735 cites W2744849445 @default.
• W3032497735 cites W2748088912 @default.
• W3032497735 cites W2751575889 @default.
• W3032497735 cites W2761026994 @default.
• W3032497735 cites W2771961325 @default.
• W3032497735 cites W2772391116 @default.
• W3032497735 cites W2789610606 @default.
• W3032497735 cites W2793992337 @default.
• W3032497735 cites W2806832126 @default.
• W3032497735 cites W2809724091 @default.
• W3032497735 cites W2885504032 @default.
• W3032497735 cites W2887249435 @default.
• W3032497735 cites W2891851920 @default.
• W3032497735 cites W2902775411 @default.
• W3032497735 cites W2911188335 @default.
• W3032497735 cites W2922846877 @default.
• W3032497735 cites W2934922729 @default.
• W3032497735 cites W2935709215 @default.
• W3032497735 cites W2955400323 @default.
• W3032497735 cites W2969131345 @default.
• W3032497735 cites W2996791478 @default.
• W3032497735 cites W4211213741 @default.
• W3032497735 doi "https://doi.org/10.1210/clinem/dgaa309" @default.
• W3032497735 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32459310" @default.
• W3032497735 hasPublicationYear "2020" @default.
• W3032497735 type Work @default.
• W3032497735 sameAs 3032497735 @default.
• W3032497735 citedByCount "12" @default.
• W3032497735 countsByYear W30324977352021 @default.
• W3032497735 countsByYear W30324977352022 @default.
• W3032497735 countsByYear W30324977352023 @default.
• W3032497735 crossrefType "journal-article" @default.
• W3032497735 hasAuthorship W3032497735A5001732123 @default.
• W3032497735 hasAuthorship W3032497735A5010806417 @default.
• W3032497735 hasAuthorship W3032497735A5012545118 @default.
• W3032497735 hasAuthorship W3032497735A5029816917 @default.
• W3032497735 hasAuthorship W3032497735A5033383665 @default.
• W3032497735 hasAuthorship W3032497735A5033986181 @default.
• W3032497735 hasAuthorship W3032497735A5047900312 @default.
• W3032497735 hasAuthorship W3032497735A5055388661 @default.
• W3032497735 hasAuthorship W3032497735A5066521865 @default.
• W3032497735 hasAuthorship W3032497735A5073501391 @default.
• W3032497735 hasAuthorship W3032497735A5081360289 @default.
• W3032497735 hasAuthorship W3032497735A5085653336 @default.
• W3032497735 hasBestOaLocation W30324977351 @default.
• W3032497735 hasConcept C121608353 @default.
• W3032497735 hasConcept C126322002 @default.
• W3032497735 hasConcept C134018914 @default.
• W3032497735 hasConcept C151730666 @default.
• W3032497735 hasConcept C167672396 @default.

• next