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- W3032503453 abstract "Imatinib and the second generation tyrosine kinase inhibitors(TKI) not only have revolutionized the management of patients with CML,but also become a model for the development of novel targeting agents in treating malignancies. Under IM treatment.more than 90%CML-CP patients could achieve complete hematologic remission,and more than 80% patients could achieve CCyR/MMoR.,the event free survival at 6-7 years were around 80%.resulting in a major change in the natural history of CML.Nevetherless, TKI cannot eliminate the bcr-abl fusion gene or CML stem cells.the patients have to take the medicine continuously or for life long,More than 10%patients developing resistance Or intolerance are also problematic.The available TKI are preferable choice for treatment of CMLKey words: Leukemia myeloid; chronic; Tyrosine kinase inhibitors; Fusion proteins; bcr-abl; Point mutation" @default.
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- W3032503453 date "2009-12-25" @default.
- W3032503453 modified "2023-09-23" @default.
- W3032503453 title "Modern treatment of chronic myeloid leukemia" @default.
- W3032503453 doi "https://doi.org/10.3760/cma.j.issn.1009-9921.2009.12.001" @default.
- W3032503453 hasPublicationYear "2009" @default.
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