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- W3032504010 abstract "Lymphatic endothelial cells (LECs) lining lymphatic vessels develop specialized cell-cell junctions that are crucial for the maintenance of vessel integrity and proper lymphatic vascular functions. Successful lymphatic drainage requires a division of labor between lymphatic capillaries that take up lymph via open ‘button-like’ junctions, and collectors that transport lymph to veins, which have tight ‘zipper-like’ junctions that prevent lymph leakage. In recent years, progress has been made in the understanding of these specialized junctions, as a result of the application of state-of-the-art imaging tools and novel transgenic animal models. In this review, we discuss lymphatic development and mechanisms governing junction remodeling between button and zipper-like states in LECs. Understanding lymphatic junction remodeling is important in order to unravel lymphatic drainage regulation in obesity and inflammatory diseases and may pave the way towards future novel therapeutic interventions." @default.
- W3032504010 created "2020-06-05" @default.
- W3032504010 creator A5000814065 @default.
- W3032504010 creator A5020432988 @default.
- W3032504010 creator A5068100568 @default.
- W3032504010 creator A5071060000 @default.
- W3032504010 date "2020-05-29" @default.
- W3032504010 modified "2023-10-03" @default.
- W3032504010 title "Lymphatic Endothelial Cell Junctions: Molecular Regulation in Physiology and Diseases" @default.
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