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- W3032511171 abstract "ObjectiveTo examine the expression of hemeoxygenase(HO)-1 and hemeoxygenase-2 in placenta tissue and changes of its byproduct carbon monoxide(CO)in peripheral blood between patients with the hypertensive disorder complicating pregnancy and women with normotensive late pregnancy,so as to explore the role of hemeoxygenase in the pathogenesis of hypertensive disorder complicating pregnancy.MethodsThe expression and localization of HO-1 mRNA and HO-2 mRNA in placenta tissue of the hypertensive disorder complicating pregnancy(the test group, n=30; the test group A had 8 cases of slight hypertensive disorder complicating pregnancy,the test group B had 22 cases of severe hypertensive disorder complicating pregnancy)and normotensive late pregnancy(the control group, n= 26)were detected by in situ hybridization and immunohistochemistry. In addition, the level of carbon monoxide- hemoglobin(COHb)in peripheral blood was studied by medical-image measure system.Results①The expression of HO-1 mRNA and HO-2 mRNA in placental trophoblast cells and vascular endothelial cells in the test group had no significant difference compared with those in the control group(P>0. 05).②The expression of hemeoxygenase-1 in placental trophoblast cells had a significantly reduced in placenta from the test group, compared with the control group(P<0. 05). The expression of hemeoxygenase-2 in placental trophoblast cells and vascular endothelium cells were significantly lower than those in the control group(P<0.05). The expression of hemeoxygenase-1 and hemeoxygenase-2 protein in the test group A were significantly higher than those in the test group B(P<0.05).③The level of carbon monoxidehemoglobin in peripheral blood in the test group was significant lower than that in the control group(P<0.05).ConclusionThe hemeoxygenase may be involved in the pathogenesis of the hypertensive disorder complicating pregnancy.Key words: hemeoxygenase; hypertensive disorder complicating pregnancy; placenta" @default.
- W3032511171 created "2020-06-05" @default.
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- W3032511171 date "2008-08-01" @default.
- W3032511171 modified "2023-09-28" @default.
- W3032511171 title "Study on the Role of Hemeoxygenase in the Pathogenesis of Hypertensive Disorder Complicating Pregnancy" @default.
- W3032511171 doi "https://doi.org/10.3760/cma.j.issn.1673-5250.2008.04.108" @default.
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